Product Identification

Product Name

3,3-Dimethyl-7-oxo-6-(2-phenyl-acetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt

Synonyms

(Trifluoromethyl)acetylene
3,3,3-Trifluoroprop-1-yne
3,3,3-Trifluoropropyne
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl acetamido)-, monosodium salt
Crystapen
Novocillin
Sodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Veticillin

CAS

661-54-1

CAS

69-57-8

Formula

C16H17N2NaO4S

Formula

C3HF3

Molecular Weight

356.37

EINECS

200-710-2

EINECS

211-548-7

RTECS

XH9800000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product

Beilstein/Gmelin

1740172

Beilstein/Gmelin

3834217

Beilstein Reference

4-01-00-00962

Beilstein Reference

4-27-00-05861

Physical and Chemical Properties

Appearance

White to slightly yellow crystalline powder with a faint odor.

Melting Point

255

Boiling Point

18

Density

1.38 g/cm3

Usage

Antibiotic.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Ingestion

Seek medical assistance.

Inhalation

Vapors may cause dizziness or asphyxiation without warning. Some may be irritating if inhaled at high concentrations.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Skin

Remove and isolate contaminated clothing and shoes. Clothing frozen to the skin should be thawed before being removed. In case of contact with liquefied gas, thaw frosted parts with lukewarm water

Skin

Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.

Eyes

May cause irritation.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Eyes

Flush with running water for at least 20 minutes.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion

See inhalation.

Inhalation

This chemical is a strong allergen and the reaction may be severe in susceptible people. Symptoms of exposure to this compound include hypersensitivity, skin rashes (ranging from maculopapular eruptions to exfoliative dermatitis), urticaria, chills, fever, edema, arthralgia, prostration, severe and occasionally fatal anaphylaxis, hemolytic anemia, leukopenia, thrombocytopenia, neuropathy and nephropathy. Subsequent exposures can lead to more serious reactions of the serum sickness type.

Skin

See inhalation.

Eyes

See inhalation

Hazards

Vapors from liquefied gas are initially heavier than air and spread along ground. Vapors may travel to source of ignition and flash back. Containers may explode when heated.

EC Risk Phrase

R 11

EC Safety Phrase

S 9 16 23 33

UN (DOT)

3161

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Personal Protection

Wear appropriate protective gloves, clothing and goggles. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Fire Fighting Measures

Fire Fighting

Extinguish fire with flooding quantities of water or use dry chemical or carbon dioxide.

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This material is probably combustible.

Fire Potential

EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Small spills/leaks

Make no contact with the spilled material. ELIMINATE all ignition sources, combustibles and ground all equipment. Take up with sand or other noncombustible absorbent material and place into containers for later disposal.

Stability and Reactivity

Incompatibilities

Incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents Incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides Incompatible with naphthalene oils and vitamin B.

Stability

No data.

Transport Information

UN Number

3161