Product Identification

Product Name

Cisplatin

Synonyms

Cisplatin
cis-Platinous diaminodichloride
Diamminedichloroplatinum

CAS

15663-27-1

Formula

Cl2H6N2Pt

Molecular Weight

300.05

EINECS

239-733-8

RTECS

TP2450000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

13,2341

Beilstein/Gmelin

2519 (G)

Physical and Chemical Properties

Appearance

An anticancer drug. Orange-yellow to deep yellow solid or powder.

Solubility in water

Soluble

Density

3.738 g/m3

Usage

Medication: antineoplastic agent.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Handling and Storage

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes. Do not breathe dust.

Hazards Identification

Inhalation

Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. May cause sneezing, runny nose, cough, and asthma. May cause anaphyla xis in some individuals. Symptoms may be similar to those described f or ingestion.

Skin

Causes skin burns. May be absorbed through the skin. May cause severe dermatitis and urticaria(hives). May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.

Eyes

Causes eye burns. Lachrymator. May cause chemical conjunctivitis and corneal damage.

Ingestion

May be fatal if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause systemic effects. May cause kidney and liver damage. Causes hearing effects (decrease in hearing). May cause nausea and vomiting. May cause damage to peripheral nervous system. May cause anaphylaxis in some individuals.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 45 23/24/25

EC Safety Phrase

S 53 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed. Chronic exposure may cause reproductive disorders and teratogenic effects. This is an experimental neoplastigen, tumorigen, and carcinogen. Reproductive effects have been reported in humans. Potential cancer hazard.

Exposure limit(s)

NIOSH REL: TWA 1 mg/m3

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen chloride, nitrogen oxides, ammonia.

Combustion Products

Toxic gases and vapors (such as chlorine) may be released when chlorine-containing soluble platinum salts decompose.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III