Product Identification

Product Name

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid

Synonyms

(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
17b-[1-Methyl-3-carboxypropyl]etiocholane-3a,7a,12a-triol
5b-Cholanic acid-3a,7a,12a-triol
5b-Cholic acid
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3a,5b,7a,12a)-

CAS

81-25-4

Formula

C24H40O5

Molecular Weight

408.57

EINECS

201-337-8

RTECS

FZ9350000

RTECS Class

Mutagen

Merck

13,2223

Beilstein/Gmelin

2822009

Beilstein Reference

4-10-00-02072

Physical and Chemical Properties

Appearance

White.

Solubility in water

Insoluble

Melting Point

199

Boiling Point

545

pKa/pKb

4.76 (pKa)

Partition Coefficient

3.04

Usage

One of two major bile acids produced by the liver where it is synthesized from cholesterol.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Keep container closed when not in use.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

The toxicological properties of this substance have not been fully investigated.

Inhalation

The toxicological properties of this substance have not been fully investigated.

Skin

No information regarding skin irritation and other potential effects was found.

Eyes

May cause eye irritation. No information regarding eye irritation and other potential effects was found.

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizers.

Decomposition

Irritating and toxic fumes and gases.