Product Identification

Product Name

Picolinonitrile

Synonyms

2-Cyanopyridine
Picolinonitrile
Pyridine-2-carbonitrile

CAS

100-70-9

Formula

C6H4N2

Molecular Weight

104.11

EINECS

202-880-3

Beilstein/Gmelin

107710

Beilstein Reference

5-22-02-00019

EC Class

harmful, irritant

Physical and Chemical Properties

Appearance

Needles or prisms from ether.

Solubility in water

Insoluble

Melting Point

26 - 28

Boiling Point

212

Vapor Pressure

0.5 (25 C)

Density

1.0810 g/cm3 (25 C)

Partition Coefficient

.45

Heat Of Vaporization

58.5 kJ/mol

Heat Of Combustion

-3143 kJ/mol

Usage

Chemical intermediate for rimiterol hydrobromide, a bronchodilator.

Vapor Density

3.6

Refractive Index

1.5242 (25 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.

Hazards Identification

Inhalation

Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

Causes skin irritation. The toxicological properties of this material have not been fully investigated.

Eyes

Causes eye irritation.

Ingestion

Causes gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 20/21/22 36/38

EC Safety Phrase

S 26 36/37/39

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation. <br>Animal studies on chick for substituted pyridines have shown teratogenicity. Injected chicken eggs develop leg and skeletal malformations.

Poison Class

3

Fire Fighting Measures

Flash Point

89

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

6

Incompatibilities

Oxidizing agents.

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III

HS Code

2933 39 99