Product Identification

Product Name

17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

Synonyms

17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
Celupan
n-Cyclopropylmethyl-14-hydroxydihydromorphinone
Trexan
Um-792

CAS

16590-41-3

Formula

C20H23NO4

Molecular Weight

341.41

EINECS

240-649-9

RTECS

QD2155000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,6450

Beilstein/Gmelin

3596648

Physical and Chemical Properties

Appearance

Crystals from acetone.

Solubility in water

2038 mg/L

Melting Point

168-170

Vapor Pressure

2.0e-16

Partition Coefficient

.534

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Respiratory failure occurred in animal studies following acute toxic doses. Pulmonary edema may result from abrupt reversal of opioid effects.

Ingestion

Nausea, vomiting, diarrhea, dry mouth and dyspepsia may occur following therapeutic or overdoses.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Blood pressure may be increased (more probable) or decreased in the event of an overdose. Increased pulse rate may occur. Fever may occur. seizures resulting in death occurred in acute toxicity studies in animals. More common adverse effects of these agents include tremors, insomnia, dizziness, nervousness and anxiety.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.