Product Identification

Product Name

Loteprednol etabonate

Synonyms

Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11b,17a)-
Lotemax

CAS

82034-46-6

Formula

C24H31ClO7

Molecular Weight

466.96

Merck

12,5614

Physical and Chemical Properties

Melting Point

220.5-223.5

Vapor Pressure

6.7E-17 (25 C)

Density

1.31 g/cm3 (20 C)

pKa/pKb

14.09 (pKa)

Partition Coefficient

3.17

Usage

A corticosteroid used in ophthalmology.

Handling and Storage

Storage

Store in original container in a cool dark place.

Hazards Identification

Inhalation

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.

Skin

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.

Eyes

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Ingestion

If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity

Combustion Products

Emits toxic fumes under fire conditions.