Product Identification

Product Name

7-(Thiophene-2-acetamido)cephalosporanic acid sodium salt

Synonyms

3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
7-(Thiophene-2-acetamido)cephalosporin
7-[2-(2-Thienyl)acetylamido]cephalosporanic acid
Averon-1
Cemastin
Cephalotin

CAS

153-61-7

Formula

C16H16N2O6S2

Molecular Weight

396.44

EINECS

205-815-7

RTECS

XI0388000

RTECS Class

Drug; Mutagen; Reproductive Effector

Merck

12,2028

Beilstein/Gmelin

945586

Physical and Chemical Properties

Solubility in water

Very soluble

Melting Point

160-160.5

pKa/pKb

2.68 (pKa)

Partition Coefficient

-0.41 (pH 2.0)

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Skin

Contact dermatitis may occur due to hypersensitivity reactions.

Ingestion

Diarrhea, nausea, vomiting, and abdominal pain may occur.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

drowsiness, myoclonus, seizures, and coma may occur following large iv doses. Neurological side effects may be more common in patients with impaired renal function.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.