Product Identification

Product Name

17beta-Hydroxy-2,4,17alpha-pregnadien-20-yno[2,3-d]isoxazole

Synonyms

17b-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole
Danazol
Danocrine
Danol
Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, (17a)-

CAS

17230-88-5

Formula

C22H27NO2

Molecular Weight

337.46

EINECS

241-270-1

RTECS

TU4157070

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone

Merck

12,2875

Beilstein/Gmelin

1088173

Beilstein Reference

5-27

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

225

Boiling Point

478

Vapor Pressure

6E-10 (25 C)

pKa/pKb

13.10 (pKa)

Heat Of Vaporization

78.2 kJ/mol

Usage

Weak androgen and anterior pituitary suppressant.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Harmful. Possible risk of harm to the unborn child. Harmful by inhalation, in contact with skin and if swallowed. Calif. Prop. 65 reproductive hazard. Target organ(s): Female reproductive system. Pituitary.

Fire Fighting Measures

Flash Point

243

Fire Fighting

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Hazards Identification

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

20/21/22 63

EC Safety Phrase

22 36