Product Identification

Product Name

Diflunisal

Synonyms

5-(2,4-Difluorophenyl)-2-hydroxybenzoic acid
5-(2,4-Difluorophenyl)salicylic acid
Fluodonil

CAS

22494-42-4

Formula

C13H8F2O3

Molecular Weight

250.2

EINECS

245-034-9

RTECS

DV2030000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,3190

Beilstein/Gmelin

2654431

Beilstein Reference

6-10

Physical and Chemical Properties

Solubility in water

Slightly soluble

Melting Point

210 - 211

Boiling Point

390

Vapor Pressure

1E-6 (25 C)

pKa/pKb

2.94 (pKa)

Partition Coefficient

4.24

Heat Of Vaporization

67.1 kJ/mol

Usage

Antiinflammatory drug.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

May be harmful if inhaled. Material is irritating to mucous membranes and upper respiratory tract.

Skin

May be harmful if absorbed through the skin.

Ingestion

Harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22 36/37/38 63

EC Safety Phrase

22 26 36

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Exposure Effects

Harmful if swallowed. Irritating to eyes, respiratory system and skin. Possible risk of harm to the unborn child. Possible sensitizer. Target organ(s): Blood. Liver.

Fire Fighting Measures

Flash Point

188

Fire Fighting

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon monoxide, Carbon dioxide, Hydrogen fluoride.