Product Identification

Product Name

8-Hydroxy-5-nitroquinoline

Synonyms

5-Nitro-8-hydroxyquinoline
5-Nitro-8-oxyquinoline
5-Nitro-8-quinolinol
5-Nitroquinolin-8-ol
Nitroxoline
Noxibiol

CAS

4008-48-4

Formula

C9H6N2O3

Molecular Weight

190.15

EINECS

223-662-4

RTECS

VC8225000

RTECS Class

Tumorigen

Merck

12,6753

Beilstein/Gmelin

166146

Beilstein Reference

5-21-03-00297

Physical and Chemical Properties

Appearance

Purple-yellow to brown powder.

Solubility in water

Very soluble

Melting Point

179 - 181

Boiling Point

419

Vapor Pressure

1E-7 (25 C)

Density

1.549 g/cm3 (22 C)

pKa/pKb

2.33 (pKa)

Partition Coefficient

2

Heat Of Vaporization

69.9 kJ/mol

Heat Of Combustion

-4283 kJ/mol

Usage

An antibiotic.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Flash Point

207

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.