Product Identification

Product Name

Quinine

Synonyms

6'-Methoxycinchonidine
Chinine
Cinchonan-9-ol, 6'-methoxy-, (8a,9R)-

CAS

130-95-0

Formula

C20H24N2O2

Molecular Weight

324.43

EINECS

205-003-2

RTECS

VA6020000

RTECS Class

Mutagen; Reproductive Effector; Human Data

Merck

12,8245

Beilstein/Gmelin

91867

Beilstein Reference

5-23-13-00395

Physical and Chemical Properties

Appearance

Triboluminescent, orthorhombic needles from absolute alcohol. Odorless. An alkaloid derived from the bark of the cinchona tree.

Solubility in water

Slightly soluble

Melting Point

176

pKa/pKb

4.87 (pKb)

Usage

Used as an antimalarial drug.

Refractive Index

1.625 (15 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

Causes skin irritation. May cause allergic contact dermatitis.

Eyes

Causes eye irritation. Contact with the eyes causes eyes to become swollen, watery, and exude a sticky viscous liquid which forms yellowish crusts. Causes visual disturbances including: blurred vision, disturbed color perception, photophobia, diplopia, night blindness, constricted visual fields, mydriasis, and possibly blindness.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Ingestion may produce visual and hearing disturbances. Human systemic effects by ingestion may include: visual field changes, tinnitus, and nausea or vomiting.

EC Risk Phrase

R 22 42/43

EC Safety Phrase

S 22 36/37 45

UN (DOT)

3335

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic ingestion may cause effects similar to those of acute ingestion.

Poison Class

3

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use agent most appropriate to extinguish fire.

Fire Potential

Slightly flammable.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures. May discolor on exposure to light.

Incompatibilities

Strong oxidizing agents - light.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Transport Information

UN Number

3335

HS Code

2939 21 10