Product Identification

Product Name

6,6',7,12-Tetramethoxy-2,2'-dimethyl-1-beta-berbaman

Synonyms

(+)-Tetrandrine
6,6',7,12-Tetramethoxy-2,2'-dimethyl-9',10',11',12',13',14'-hexadehydro-9',10',11',12',13',14'-hexahydroberbaman
6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
d-Tetrandrine
Fanchinine
Sinomenine A

CAS

518-34-3

Formula

C38H42N2O6

Molecular Weight

622.76

RTECS

XE9350000

Merck

12,9369

Beilstein/Gmelin

877811

Beilstein Reference

2-27-00-00889

Physical and Chemical Properties

Appearance

White solid.

Solubility in water

Insoluble

Melting Point

217

Vapor Pressure

4.9E-20 (25 C)

Density

1.17 g/cm3 (20 C)

pKa/pKb

6.20 (pKb)

Partition Coefficient

3.55

Usage

Immunosuppresive agent.

Handling and Storage

Storage

:Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20 C.

Hazards Identification

Inhalation

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Skin

In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.

Eyes

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.

Ingestion

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.

EC Risk Phrase

R: 20/21/22

EC Safety Phrase

S: 36

Exposure Controls/Personal Protection

Personal Protection

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Fire Fighting Measures

Fire Fighting

Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear. Extinguishing agents:

Fire Potential

May be combustible at high temperature.

Accidental Release Measures

Small spills/leaks

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).