ChemicalBook > CAS DataBase List > TIROFIBAN HYDROCHLORIDE MONOHYDRATE

TIROFIBAN HYDROCHLORIDE MONOHYDRATE

Product Name
TIROFIBAN HYDROCHLORIDE MONOHYDRATE
CAS No.
142373-60-2
Chemical Name
TIROFIBAN HYDROCHLORIDE MONOHYDRATE
Synonyms
Tirofiban Hydrochloride;butoxy);L 700462;4-Dihydroxypyridine;-3-(4-(4-(piperidin-4-yl);TirofibanhydrochlorideHCl;Tirofiban hydrochloride 1-hydrate;Tirofiban hydrochloride (L700462);Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride;N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride
CBNumber
CB0100160
Molecular Formula
C22H39ClN2O6S
Formula Weight
495.07
MOL File
142373-60-2.mol
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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Property

Melting point:
83-87oC
solubility 
Methanol (Slightly)
form 
Solid
color 
White
CAS DataBase Reference
142373-60-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0014445
Product name
TIROFIBAN HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$501.15
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
53173
Product name
TirofibanHCl
Packaging
10mg
Price
$570
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014445
Product name
TIROFIBAN HYDROCHLORIDE
Purity
95.00%
Packaging
250MG
Price
$898.8
Updated
2021/12/16
Chemenu
Product number
CM195483
Product name
(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride
Purity
97%
Packaging
1g
Price
$1117
Updated
2021/12/16
Crysdot
Product number
CD21014226
Product name
(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride
Purity
97%
Packaging
1g
Price
$1186
Updated
2021/12/16
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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Chemical Properties,Usage,Production

Description

Tirofiban was launched as Aggrastat in Switzerland and the US for patients with unstable angina or non-Q-wave myocardial infarction to prevent cardiac ischemic events. Tirofiban is synthesized from (S)-tyrosine by a fourstep process. Tirofiban is a novel highly potent antiplatelet agent that inhibits the interaction of fibrinogen with GPⅡb/Ⅲa, an activated platelet membrane-bound glycoprotein complex. It prevents arterial thrombus formation in a dosedependent manner. Clinical efficacy was highly significant with an absolute and relative risk reduction. In these studies, treatment with tirofiban was well tolerated, without significant adverse effects.

Originator

Sibutramine (Sibutramine)

Uses

Aggrastat (Millot Laboratories, France).

Uses

Tirofiban Hydrochloride is a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist.

Manufacturing Process

The synthesis of tirofiban starts by reaction of tyrosine with bis-trimethylsilyl trifluoraceramide to give a derivative in which both functions -OH and COOH_x0002_are protected. Treatment of this intermediate with butylsulfonyl chloride gives the corresponding sulfonamide derivative; the quite labile silyl groups are then removed under mildly acidic conditions to give N-butylsulfonyl-tyrosine. In a parallel scheme, 4-picoline is converted to its anion by means of butyl lithium; this gives 4-(4-chlorobutyl)-pyridine on alkylation with 1-bromo-3- chloropropane. The reaction of this compound with N-butylsulfonyl-tyrosine in presence of NaOH gives the ether 2-butylsulfonyaminol-3-[4-pyridin-4-ylbutoxy-phenyl]propionic acid. Hydrogenation over palladium on charcoal then reduce the pyridine ring to a piperidine to afford the fibrinogen receptor antagonist tirofiban.

brand name

Tirofiban is INN and BAN.

Therapeutic Function

Fibrinogen receptor antagonist

TIROFIBAN HYDROCHLORIDE MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Suppliers

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View Lastest Price from TIROFIBAN HYDROCHLORIDE MONOHYDRATE manufacturers

Dideu Industries Group Limited
Product
TIROFIBAN HYDROCHLORIDE MONOHYDRATE 142373-60-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-06
Shaanxi Dideu Medichem Co. Ltd
Product
Tirofiban hydrochloride 142373-60-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11
Career Henan Chemical Co
Product
TIROFIBAN HYDROCHLORIDE MONOHYDRATE 142373-60-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

142373-60-2, TIROFIBAN HYDROCHLORIDE MONOHYDRATERelated Search:

Tirofiban hydrochloride monohydrate L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) tirofiban N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine 4-PYRIDIN-4-YL-BUTAN-1-OL 1-Butanesulfonic acid methyl ester 4-PYRIDIN-4-YL-BUTYRIC ACID Sodium 1-butanesulfonate 1-Methylethyl 1-butanesulfonate METHYL N-BUTYLSULFONYL-L-P-HYDROXYPHENYLALANINE tirofiban tirofiban 1-Butanesulfonyl chloride 4-(4-Piperidyl)-1-butanol 2-butyl-4-methylpyridine 4,4'-Dimethyl-2,2'-bipyridyl 4-Chloro-1-butanol

  • L 700462
  • L-Tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, monohydrochloride
  • N-(Butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride
  • 2-(butylsulfonaMido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid
  • L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride (1:1)
  • -3-(4-(4-(piperidin-4-yl)
  • butoxy)
  • N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride
  • Tirofiban Hydrochloride
  • TirofibanhydrochlorideHCl
  • (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride
  • Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride
  • 2-(butylsulfonylamino)-3-[4-[4-(4-piperidinyl)butoxy]phenyl]propanoic acid hydrochloride
  • (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid
  • Tirofiban hydrochloride 1-hydrate
  • Tirofiban hydrochloride (L700462)
  • 4-Dihydroxypyridine
  • 142373-60-2
  • C22H36N2O5SHCl
  • C22H36N2O5SHClH2O
  • C22H39ClN2O6S
  • C23H40ClNO6S
  • C22H36N2O5SClH