ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMO-3-IODOPYRIDINE

2-AMINO-5-BROMO-3-IODOPYRIDINE

Product Name
2-AMINO-5-BROMO-3-IODOPYRIDINE
CAS No.
381233-96-1
Chemical Name
2-AMINO-5-BROMO-3-IODOPYRIDINE
Synonyms
5-Bromo-3-iodopyridin-2-amine;5-Bromo-3-iodo-2-pyridinamine;2-AMINO-5-BROMO-3-IODOPYRIDINE;5-Bromo-3-iodo-2-aminopyridine;2-PyridinaMine,5-broMo-3-iodo-;2-Amine-5-bromo-3-iodopyridine;2-Amino-3-iodo-5-bromopyridine;5-BROMO-3-IODO-PYRIDIN-2-YLAMINE;2-Amino-5-bromo-3-iodopyridine 96%;2-AMINO-5-BROMO-3-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber
CB0100973
Molecular Formula
C5H4BrIN2
Formula Weight
298.91
MOL File
381233-96-1.mol
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2-AMINO-5-BROMO-3-IODOPYRIDINE Property

Melting point:
111-112°C
Boiling point:
308.2±42.0 °C(Predicted)
Density 
2.426±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.25±0.49(Predicted)
color 
White to Yellow to Orange
Sensitive 
Light Sensitive
InChI
InChI=1S/C5H4BrIN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)
InChIKey
XPERZSKJGNUSHI-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C=C1I
CAS DataBase Reference
381233-96-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-36:37/38-41-37/38-22
Safety Statements 
26-36/37/39-37
WGK Germany 
3
HazardClass 
IRRITANT, LIGHT SENSITIVE
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
704032
Product name
2-Amino-5-bromo-3-iodopyridine
Purity
97%
Packaging
1g
Price
$65.24
Updated
2025/07/31
TCI Chemical
Product number
A2563
Product name
2-Amino-5-bromo-3-iodopyridine
Purity
>98.0%(T)
Packaging
1g
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
A2563
Product name
2-Amino-5-bromo-3-iodopyridine
Purity
>98.0%(T)
Packaging
5g
Price
$232
Updated
2025/07/31
TRC
Product number
A577140
Product name
2-AMINO-5-BROMO-3-IODOPYRIDINE
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
048725
Product name
2-Amino-5-bromo-3-iodopyridine
Purity
97%
Packaging
1g
Price
$10
Updated
2021/12/16
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2-AMINO-5-BROMO-3-IODOPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Brown powder

Uses

2-Amino-5-Bromo-3-Iodopyridine is used as an important intermediate of pharmaceuticals and farm chemicals.

Synthesis

1072-97-5

381233-96-1

The general steps for the synthesis of 2-amino-3-iodo-5-bromopyridine from 2-amino-5-bromopyridine are as follows: Step 1: Iodination reaction 5-Bromo-pyridin-2-ylamine (50 g, 289 mmol) was dissolved in 2 M sulfuric acid (500 mL) and potassium iodate (30.8 g, 144 mmol) was added in batches. The mixture was heated to 100°C and an aqueous solution of potassium iodide (26.5 g, 160 mmol) was added slowly and dropwise (50 mL) over about 1 hour. After 1 hour of reaction, stirring was continued for 30 minutes, followed by cooling to room temperature. The pH of the aqueous phase was adjusted to 8-9 with alkali and then the mixture was extracted with ethyl acetate (3 times). The organic layers were combined and washed sequentially with aqueous sodium thiosulfate, water and brine, dried (Na2SO4) and concentrated to give 2-amino-3-iodo-5-bromopyridine as a brown solid (77.4 g, 90% yield). NMR data (300 MHz, CDCl3): δ 8.06 (d, J = 2.2 Hz, 1H), 7.96 (d, J = 2.2 Hz, 1H), 4.96 (s, 2H).

References

[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 38, p. 10093 - 10096
[2] Angew. Chem., 2013, vol. 52, # 38, p. 10093 - 10096,4
[3] Patent: WO2011/73263, 2011, A1. Location in patent: Page/Page column 78
[4] Patent: WO2012/10538, 2012, A2. Location in patent: Page/Page column 28
[5] Patent: US2012/22258, 2012, A1. Location in patent: Page/Page column 13-14

2-AMINO-5-BROMO-3-IODOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMO-3-IODOPYRIDINE Suppliers

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View Lastest Price from 2-AMINO-5-BROMO-3-IODOPYRIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-AMINO-5-BROMO-3-IODOPYRIDINE 381233-96-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-07-10
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-Bromo-3-iodopyridin-2-amine 381233-96-1
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Hebei Fengjia New Material Co., Ltd
Product
2-Amino-5-bromo-3-iodopyridine 381233-96-1
Price
US $4.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-08

381233-96-1, 2-AMINO-5-BROMO-3-IODOPYRIDINERelated Search:

2-(Boc-amino)-5-bromopyridine Pyridinium tribromide 3-AMINO-6-BROMO-2-CHLOROPYRIDINE 2-Bromo-3-hydroxypyridine 2-AMINO-5-CHLORO-3-PICOLINE 3-BROMO-6-HYDROXY-2-METHYLPYRIDINE 2,6-Dibromopyridin-3-amine 6-BROMO-BENZOXAZOLINONE 5-Bromo-2-chloropyridine-3-carboxamide 2-AMINO-3-CHLORO-5-BROMOPYRIDINE 2-AMINO-5-CHLORO-3-IODOPYRIDINE 4'-BROMO-2,2':6',2''-TERPYRIDINE 3-Iodopyridine 3-Iodopyridin-2-amine 3-Bromo-5-iodo-pyridine 2-AMINO-5-BROMO-3-IODOPYRIDINE 2-AMINO-3-IODO-5-BROMO-6-METHYLPYRIDINE N-ACETYL-N-(5-BROMO-3-IODO-PYRIDIN-2-YL)-ACETAMIDE

  • 2-AMINO-5-BROMO-3-IODOPYRIDINE
  • 5-BROMO-3-IODO-PYRIDIN-2-YLAMINE
  • 2-Amino-3-iodo-5-bromopyridine
  • 5-Bromo-3-iodopyridin-2-amine
  • 2-Amine-5-bromo-3-iodopyridine
  • 5-Bromo-3-iodo-2-pyridinamine
  • 2-Amino-5-bromo-3-iodopyridine 96%
  • 2-PyridinaMine,5-broMo-3-iodo-
  • 5-Bromo-3-iodo-2-aminopyridine
  • 2-AMINO-5-BROMO-3-IODOPYRIDINE ISO 9001：2015 REACH
  • 381233-96-1
  • C5H4BrlN2
  • C5H4BrIN2
  • Iodide
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • pharmacetical
  • Amines
  • pyridine
  • Building Blocks
  • C5
  • C5 to C6
  • Chemical Synthesis