2-AMINO-5-CHLORO-3-IODOPYRIDINE

Product Name: 2-AMINO-5-CHLORO-3-IODOPYRIDINE
CAS No.: 211308-81-5
Chemical Name: 2-AMINO-5-CHLORO-3-IODOPYRIDINE
Synonyms: 5-Chloro-3-iodopyridin-2-amine;5-chloro-3-iodo-2-pyridinamine;2-AMINO-5-CHLORO-4-IODOPYRIDINE;2-AMINO-5-CHLORO-3-IODOPYRIDINE;2-amino-3-iodo-5-chloropyridine;2-PyridinaMine, 5-chloro-3-iodo-;5-CHLORO-3-IODO-PYRIDIN-2-YLAMINE;2-AMINO-5-CHLORO-3-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber: CB1750449
Molecular Formula: C5H4ClIN2
Formula Weight: 254.46
MOL File: 211308-81-5.mol

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2-AMINO-5-CHLORO-3-IODOPYRIDINE Property

Melting point:: 137-138°C
Boiling point:: 306.9±42.0 °C(Predicted)
Density: 2.139±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder to crystal
pka: 2.27±0.49(Predicted)
color: Light yellow to Yellow to Orange
Sensitive: Light Sensitive
CAS DataBase Reference: 211308-81-5

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
PackingGroup: III
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000363
Product name: 5-Chloro-3-iodo-pyridin-2-ylamine
Purity: Aldrich
Packaging: 1g
Price: $482
Updated: 2024/03/01

TCI Chemical

Product number: A3069
Product name: 2-Amino-5-chloro-3-iodopyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: A3069
Product name: 2-Amino-5-chloro-3-iodopyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $231
Updated: 2025/07/31

TRC

Product number: A603215
Product name: 2-Amino-5-chloro-3-iodopyridine
Packaging: 1g
Price: $140
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-M-05
Product name: 2-Amino-5-chloro-3-iodopyridine
Packaging: 5G
Price: $96
Updated: 2021/12/16

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2-AMINO-5-CHLORO-3-IODOPYRIDINE Chemical Properties,Usage,Production

Uses

2-Amino-5-chloro-3-iodopyridine is a useful synthetic intermediate. It was used in the rational design of highly selective spleen tyrosine kinase inhibitors. It was also used to synthesize azaindole derivatives with antibacterial and antifungal activities.

Synthesis

1072-98-6

211308-81-5

GENERAL STEPS: 24,150 mL of a solvent mixture of tetrahydrofuran and 50 L of ethylene dichloride were added to an 8000 mL reactor, a plug-in thermometer was installed and a mechanical stirrer was started. Subsequently, 6037.5 g of 2-amino-5-chloropyridine and 18528 g of N-iodosuccinimide were added to the reactor. The reaction mixture was stirred continuously at 53 °C for 7 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC) to confirm the complete reaction of 2-amino-5-chloropyridine. Upon completion of the reaction, the solvent was removed using a rotary evaporator to give the crude product. The crude product was recrystallized by a solvent mixture of ethyl acetate and ethanol to obtain purified 2-amino-3-iodo-5-chloropyridine. The product was dried and the calculated yield was 90.10% and the purity was 98.2% by GC.

References

[1] Patent: CN104744353, 2017, B. Location in patent: Paragraph 0017-0031
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 2, p. 307 - 315
[3] Patent: US2014/18533, 2014, A1. Location in patent: Paragraph 0074; 0075
[4] Patent: WO2011/73263, 2011, A1. Location in patent: Page/Page column 88-89
[5] Patent: WO2005/95400, 2005, A1. Location in patent: Page/Page column 345-346

2-AMINO-5-CHLORO-3-IODOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-CHLORO-3-IODOPYRIDINE Suppliers

Americas 1 China 118 Europe 1 France 2 Germany 1 India 7 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 30 Global 170

J & K SCIENTIFIC LTD.

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View Lastest Price from 2-AMINO-5-CHLORO-3-IODOPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 2-AMINO-5-CHLORO-3-IODOPYRIDINE 211308-81-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

Career Henan Chemical Co

Product: 2-AMINO-5-CHLORO-3-IODOPYRIDINE 211308-81-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

211308-81-5, 2-AMINO-5-CHLORO-3-IODOPYRIDINERelated Search:

2-Amino-3-bromo-5-chloropyridine 2-AMINO-3-CHLORO-5-FLUOROPYRIDINE 2-Amino-3-bromo-5-fluoropyridine 3-BROMO-5-IODOPYRIDIN-2-AMINE 3,5-Dibromo-2-pyridylamine 2-Amino-3,5-dichloropyridine 5-Bromo-2-chloropyridine-3-carboxamide 2-AMINO-3-CHLORO-5-BROMOPYRIDINE 2-AMINO-5-BROMO-3-IODOPYRIDINE 3-Iodopyridine 4-Iodopyridine 2-AMINO-5-CHLORO-3-IODOPYRIDINE 3-Iodopyridin-2-amine 5-CHLORO-3-IODOPYRIDIN-2-YLHYDRAZINE 3-CHLORO-5-IODO-PYRIDINE 2-AMINO-3-IODO-5-CHLORO-6-METHYLPYRIDINE 3-AMINO-2-CHLORO-5-IODOPYRIDINE 3-Amino-2-chloro-6-iodopyridine,3-Amino-6-chloro-2-iodopyridine

2-AMINO-5-CHLORO-3-IODOPYRIDINE

5-CHLORO-3-IODO-PYRIDIN-2-YLAMINE

2-AMINO-5-CHLORO-4-IODOPYRIDINE

5-chloro-3-iodo-2-pyridinamine

5-Chloro-3-iodopyridin-2-amine

2-PyridinaMine, 5-chloro-3-iodo-

2-amino-3-iodo-5-chloropyridine

2-AMINO-5-CHLORO-3-IODOPYRIDINE ISO 9001：2015 REACH

211308-81-5