2-Amino-3-bromo-5-fluoropyridine

Product Name: 2-Amino-3-bromo-5-fluoropyridine
CAS No.: 869557-43-7
Chemical Name: 2-Amino-3-bromo-5-fluoropyridine
Synonyms: 2-Amino-3-bromo-5-fL;3-Bromo-5-fluoro-2-pyridinamine;3-Bromo-5-fluoropyridin-2-amine;2-AMINO-3-BROMO-5-FLUOROPYRIDINE;2-Pyridinamine, 3-bromo-5-fluoro-;2-AMINO-5-FLUORO-3-BROMO PYRIDINE;3-BroMo-5-fluoro-pyridin-2-ylaMine;2-Amino-3-bromo-5-fluoropyridine 97%;2-Amino-3-bromo-5-fluoropyridine ISO 9001：2015 REACH
CBNumber: CB5419603
Molecular Formula: C5H4BrFN2
Formula Weight: 191
MOL File: 869557-43-7.mol

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2-Amino-3-bromo-5-fluoropyridine Property

Melting point:: 61-63°C
Boiling point:: 63-65℃
Density: 1.813±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.86±0.49(Predicted)
form: powder to crystal
color: White to Almost white
CAS DataBase Reference: 869557-43-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 722383
Product name: 2-Amino-3-bromo-5-fluoropyridine
Purity: 97%
Packaging: 1g
Price: $59
Updated: 2023/06/20

Sigma-Aldrich

Product number: 722383
Product name: 2-Amino-3-bromo-5-fluoropyridine
Purity: 97%
Packaging: 5g
Price: $132
Updated: 2023/06/20

TCI Chemical

Product number: A3346
Product name: 2-Amino-3-bromo-5-fluoropyridine
Packaging: 1G
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: A3346
Product name: 2-Amino-3-bromo-5-fluoropyridine
Packaging: 5G
Price: $180
Updated: 2025/07/31

Usbiological

Product number: 414993
Product name: 2-Amino-3-bromo-5-fluoropyridine
Packaging: 500mg
Price: $319
Updated: 2021/12/16

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2-Amino-3-bromo-5-fluoropyridine Chemical Properties,Usage,Production

Uses

2-Amino-3-bromo-5-fluoropyridine is a reactant used in the synthesis of cyano heteroaryl bromides.

Synthesis

21717-96-4

869557-43-7

The general procedure for the synthesis of 2-amino-3-bromo-5-fluoropyridine from 2-amino-5-fluoropyridine is as follows: Method C: Bromination reaction using sulfuric acid (H2SO4). This was done as follows: a solution of 93% sulfuric acid (12.5 kg, 119 mol) in water (26 L) was added to a 50 L reactor, followed by 2-amino-5-fluoropyridine (6.5 kg, 58 mol). The reaction temperature was adjusted to 30 °C and then bromine (10 kg, 63 mol) was added in 10 portions over 3 hours. The reaction mixture was stirred at 45 °C for 18 hours, followed by continued stirring at 50 °C for 5 hours. Upon completion of the reaction, the mixture was cooled to 15 °C and transferred to a 400 L reactor for post-processing. The products of the four reactions (4 x 6.5 kg) were combined and the reaction was quenched with a mixture of 50% sodium hydroxide (110 kg, 1375 mol) and sodium thiosulfate (1.8 kg, 11.4 mol) in water (100 L) at 50 °C, the quenching process lasted for 1-3 hours. The temperature was adjusted to 32 °C, the slurry was filtered and washed with water (80 L) to give a water-wet crude product (62 kg). The same operation was carried out for the second round of three reactions (3 x 6.5 kg of feedstock) to give a water-wet crude product (41 kg). The crude product (103 kg) was dissolved (partially insoluble) in toluene (280 kg) at 25-30 °C. After addition of brine (20 kg), phase separation could not be achieved due to the presence of solids. The mixture was filtered through a diatomaceous earth pad, washed with toluene and layered. The organic phase was concentrated to 347 L to remove residual water by azeotropy and used in the subsequent preparation of compound 3a. The product concentration was determined by aliquoting to be 181 g/L in a yield of 62.8 kg. An additional 600 g of product was obtained by extraction of the water/brine layer by ethyl acetate (10 L) and separated, which was treated by filtration through a pad of magnesium salts, evaporation, and hexane grinding. The overall yield was 82%.

References

[1] Patent: WO2015/73481, 2015, A1. Location in patent: Paragraph 0259-0260
[2] Patent: WO2016/183116, 2016, A1. Location in patent: Paragraph 0251; 0252; 0253
[3] Patent: WO2017/97234, 2017, A1. Location in patent: Paragraph 00405
[4] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 75
[5] Patent: WO2011/143365, 2011, A1. Location in patent: Page/Page column 154

2-Amino-3-bromo-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-bromo-5-fluoropyridine Suppliers

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View Lastest Price from 2-Amino-3-bromo-5-fluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-3-bromo-5-fluoropyridine 869557-43-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 2-Amino-3-bromo-5-fluoropyridine 869557-43-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-12

869557-43-7, 2-Amino-3-bromo-5-fluoropyridineRelated Search:

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869557-43-7

869577-43-7

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C5H4BrFN2

Fluorine series

Building Blocks

C5

C5 to C6

Chemical Synthesis

Fluorinated Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocyclic Fluorinated Building Blocks

Other Fluorinated Heterocycles

Boronic Acid

Amines

blocks

FluoroCompounds

Pyridines