2-Amino-3-bromo-5-fluoropyridine
- Product Name
- 2-Amino-3-bromo-5-fluoropyridine
- CAS No.
- 869557-43-7
- Chemical Name
- 2-Amino-3-bromo-5-fluoropyridine
- Synonyms
- 2-Amino-3-bromo-5-fL;3-Bromo-5-fluoro-2-pyridinamine;3-Bromo-5-fluoropyridin-2-amine;2-AMINO-3-BROMO-5-FLUOROPYRIDINE;2-Pyridinamine, 3-bromo-5-fluoro-;2-AMINO-5-FLUORO-3-BROMO PYRIDINE;3-BroMo-5-fluoro-pyridin-2-ylaMine;2-Amino-3-bromo-5-fluoropyridine 97%;2-Amino-3-bromo-5-fluoropyridine ISO 9001：2015 REACH
- CBNumber
- CB5419603
- Molecular Formula
- C5H4BrFN2
- Formula Weight
- 191
- MOL File
- 869557-43-7.mol
2-Amino-3-bromo-5-fluoropyridine Property
- Melting point:
- 61-63°C
- Boiling point:
- 63-65℃
- Density
- 1.813±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.86±0.49(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- CAS DataBase Reference
- 869557-43-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 722383
- Product name
- 2-Amino-3-bromo-5-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $59
- Updated
- 2023/06/20
- Product number
- 722383
- Product name
- 2-Amino-3-bromo-5-fluoropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $132
- Updated
- 2023/06/20
- Product number
- A3346
- Product name
- 2-Amino-3-bromo-5-fluoropyridine
- Packaging
- 1G
- Price
- $61
- Updated
- 2025/07/31
- Product number
- A3346
- Product name
- 2-Amino-3-bromo-5-fluoropyridine
- Packaging
- 5G
- Price
- $180
- Updated
- 2025/07/31
- Product number
- 414993
- Product name
- 2-Amino-3-bromo-5-fluoropyridine
- Packaging
- 500mg
- Price
- $319
- Updated
- 2021/12/16
2-Amino-3-bromo-5-fluoropyridine Chemical Properties,Usage,Production
Uses
2-Amino-3-bromo-5-fluoropyridine is a reactant used in the synthesis of cyano heteroaryl bromides.
Synthesis
21717-96-4
869557-43-7
The general procedure for the synthesis of 2-amino-3-bromo-5-fluoropyridine from 2-amino-5-fluoropyridine is as follows: Method C: Bromination reaction using sulfuric acid (H2SO4). This was done as follows: a solution of 93% sulfuric acid (12.5 kg, 119 mol) in water (26 L) was added to a 50 L reactor, followed by 2-amino-5-fluoropyridine (6.5 kg, 58 mol). The reaction temperature was adjusted to 30 °C and then bromine (10 kg, 63 mol) was added in 10 portions over 3 hours. The reaction mixture was stirred at 45 °C for 18 hours, followed by continued stirring at 50 °C for 5 hours. Upon completion of the reaction, the mixture was cooled to 15 °C and transferred to a 400 L reactor for post-processing. The products of the four reactions (4 x 6.5 kg) were combined and the reaction was quenched with a mixture of 50% sodium hydroxide (110 kg, 1375 mol) and sodium thiosulfate (1.8 kg, 11.4 mol) in water (100 L) at 50 °C, the quenching process lasted for 1-3 hours. The temperature was adjusted to 32 °C, the slurry was filtered and washed with water (80 L) to give a water-wet crude product (62 kg). The same operation was carried out for the second round of three reactions (3 x 6.5 kg of feedstock) to give a water-wet crude product (41 kg). The crude product (103 kg) was dissolved (partially insoluble) in toluene (280 kg) at 25-30 °C. After addition of brine (20 kg), phase separation could not be achieved due to the presence of solids. The mixture was filtered through a diatomaceous earth pad, washed with toluene and layered. The organic phase was concentrated to 347 L to remove residual water by azeotropy and used in the subsequent preparation of compound 3a. The product concentration was determined by aliquoting to be 181 g/L in a yield of 62.8 kg. An additional 600 g of product was obtained by extraction of the water/brine layer by ethyl acetate (10 L) and separated, which was treated by filtration through a pad of magnesium salts, evaporation, and hexane grinding. The overall yield was 82%.
References
[1] Patent: WO2015/73481, 2015, A1. Location in patent: Paragraph 0259-0260
[2] Patent: WO2016/183116, 2016, A1. Location in patent: Paragraph 0251; 0252; 0253
[3] Patent: WO2017/97234, 2017, A1. Location in patent: Paragraph 00405
[4] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 75
[5] Patent: WO2011/143365, 2011, A1. Location in patent: Page/Page column 154
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View Lastest Price from 2-Amino-3-bromo-5-fluoropyridine manufacturers
- Product
- 2-Amino-3-bromo-5-fluoropyridine 869557-43-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Amino-3-bromo-5-fluoropyridine 869557-43-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12