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Gabapentin enacarbil

Product Name
Gabapentin enacarbil
CAS No.
478296-72-9
Chemical Name
Gabapentin enacarbil
Synonyms
XP 13512;GABAPENTIN ENACARBIL;Gabapentin Enarcarbil;1-[[[[1-(2-Methyl-1-oxopropoxy)ethoxy]carbonyl]amino]methyl]cyclohexaneacetic acid;Cyclohexaneacetic acid,1-[[[[1-(2-Methyl-1-oxopropoxy)ethoxy]carbonyl]aMino]Methyl]-
CBNumber
CB01011737
Molecular Formula
C16H27NO6
Formula Weight
329.39
MOL File
478296-72-9.mol
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Gabapentin enacarbil Property

Melting point:
65 °C
Density 
1.134
CAS DataBase Reference
478296-72-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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Gabapentin enacarbil Chemical Properties,Usage,Production

Description

In April 2011, the U.S. FDA approved gabapentin enacarbil (XP- 13512) for the treatment of moderate-to-severe Restless Legs Syndrome (RLS) in adults. Gabapentin enacarbil is a novel prodrug of gabapentin that was designed to be recognized as a substrate for two high-capacity nutrient transports, monocarboxylate transporter type 1 and sodium-dependent multivitamin transporter, and to be efficiently cleaved after absorption to give gabapentin. The separated enantiomers of gabapentin enacarbil have similar cleavage rates in human tissues. Preclinical studies showed that gabapentin enacarbil provides good systemic exposure of gabapentin in rats and monkeys. Gabapentin enacarbil is prepared as a racemic mixture from gabapentin either by sequential coupling with 1-chloroethyl chloroformate in the presence of trimethylsilyl chloride and triethylamine followed by addition of isobutyric acid or by direct coupling with an activated 1-(isobutyryloxy) ethyl carbonate.

Originator

Xenoport (United States)

Definition

ChEBI: A carbamate ester that is the N-[1-(isobutyryloxy)ethoxy]carbonyl derivative of [1-(aminomethyl)cyclohexyl]acetic acid. The prodrug for gabapentin, used for treatment of neuropathic pain and restless legs syndrome.

brand name

Horizant

Gabapentin enacarbil Preparation Products And Raw materials

Raw materials

Preparation Products

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Gabapentin enacarbil Suppliers

LGM Pharma
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1-(800)-881-8210
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615-250-9817
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inquiries@lgmpharma.com
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United States
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Shanghai Fuhe Chemistry Technology Co., Ltd.
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0086-21-67651709
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0086-21-67651705
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cfx759@hotmail.com
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China
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BOC Sciences
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info@bocsci.com
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United States
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MedChemexpress LLC
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609-228-6898
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609-228-5909
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GIHI CHEMICALS CO.,LTD
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0086-571-86217390
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0086-571-86217391
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Shanghai Meishui Chemical Technology Co., Ltd
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021-60549325 18616193163
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021-33250306
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mail@meishuichem.com
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China
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ShangHai KenEn Chemical Technology Co., Ltd.
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13120367189, 18621755571
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021-50315529
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Chizhou Kailong Import and Export Trade Co., Ltd.
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Guangzhou Ciming Biological Technology Co., Ltd.
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020-38082199/29065168/38082986/29878298/29866629/4000192398
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+86 (20)38082986
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SPIRO PHARMA
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View Lastest Price from Gabapentin enacarbil manufacturers

career henan chemical co
Product
Gabapentin enacarbil 478296-72-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-23

478296-72-9, Gabapentin enacarbilRelated Search:


  • 1-[[[[1-(2-Methyl-1-oxopropoxy)ethoxy]carbonyl]amino]methyl]cyclohexaneacetic acid
  • Cyclohexaneacetic acid,1-[[[[1-(2-Methyl-1-oxopropoxy)ethoxy]carbonyl]aMino]Methyl]-
  • XP 13512
  • GABAPENTIN ENACARBIL
  • Gabapentin Enarcarbil
  • 478296-72-9