Gabapentin enacarbil
- Product Name
- Gabapentin enacarbil
- CAS No.
- 478296-72-9
- Chemical Name
- Gabapentin enacarbil
- Synonyms
- XP 13512;GABAPENTIN ENACARBIL;Gabapentin Enarcarbil;1-[[[[1-(2-Methyl-1-oxopropoxy)ethoxy]carbonyl]amino]methyl]cyclohexaneacetic acid;Cyclohexaneacetic acid,1-[[[[1-(2-Methyl-1-oxopropoxy)ethoxy]carbonyl]aMino]Methyl]-
- CBNumber
- CB01011737
- Molecular Formula
- C16H27NO6
- Formula Weight
- 329.39
- MOL File
- 478296-72-9.mol
Gabapentin enacarbil Property
- Melting point:
- 65 °C
- Density
- 1.134
- CAS DataBase Reference
- 478296-72-9(CAS DataBase Reference)
Gabapentin enacarbil Chemical Properties,Usage,Production
Description
In April 2011, the U.S. FDA approved gabapentin enacarbil (XP- 13512) for the treatment of moderate-to-severe Restless Legs Syndrome (RLS) in adults. Gabapentin enacarbil is a novel prodrug of gabapentin that was designed to be recognized as a substrate for two high-capacity nutrient transports, monocarboxylate transporter type 1 and sodium-dependent multivitamin transporter, and to be efficiently cleaved after absorption to give gabapentin. The separated enantiomers of gabapentin enacarbil have similar cleavage rates in human tissues. Preclinical studies showed that gabapentin enacarbil provides good systemic exposure of gabapentin in rats and monkeys. Gabapentin enacarbil is prepared as a racemic mixture from gabapentin either by sequential coupling with 1-chloroethyl chloroformate in the presence of trimethylsilyl chloride and triethylamine followed by addition of isobutyric acid or by direct coupling with an activated 1-(isobutyryloxy) ethyl carbonate.
Originator
Xenoport (United States)
Definition
ChEBI: A carbamate ester that is the N-[1-(isobutyryloxy)ethoxy]carbonyl derivative of [1-(aminomethyl)cyclohexyl]acetic acid. The prodrug for gabapentin, used for treatment of neuropathic pain and restless legs syndrome.
brand name
Horizant
Gabapentin enacarbil Preparation Products And Raw materials
Raw materials
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View Lastest Price from Gabapentin enacarbil manufacturers
- Product
- Gabapentin enacarbil 478296-72-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-23