Pyridine, 2-fluoro-3-methoxy- (9CI)
- Product Name
- Pyridine, 2-fluoro-3-methoxy- (9CI)
- CAS No.
- 163234-74-0
- Chemical Name
- Pyridine, 2-fluoro-3-methoxy- (9CI)
- Synonyms
- 2-Fluoro-3-methoxypyridine;Pyridine,2-fluoro-3-Methoxy-;Pyridine, 2-fluoro-3-methoxy- (9CI)
- CBNumber
- CB01047884
- Molecular Formula
- C6H6FNO
- Formula Weight
- 127.12
- MOL File
- 163234-74-0.mol
Pyridine, 2-fluoro-3-methoxy- (9CI) Property
- Boiling point:
- 190.8±20.0 °C(Predicted)
- Density
- 1.146±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.22±0.10(Predicted)
- form
- liquid
- color
- Colourless
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- F592333
- Product name
- 2-Fluoro-3-methoxypyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 041230
- Product name
- 2-Fluoro-3-methoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $46
- Updated
- 2021/12/16
- Product number
- Y15200
- Product name
- 2-Fluoro-3-methoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- PC908496
- Product name
- 2-Fluoro-3-methoxypyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 041230
- Product name
- 2-Fluoro-3-methoxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $189
- Updated
- 2021/12/16
Pyridine, 2-fluoro-3-methoxy- (9CI) Chemical Properties,Usage,Production
Synthesis
174669-74-0
74-88-4
163234-74-0
Synthesis of 2-fluoro-3-methoxypyridine (3): 2-fluoropyridin-3-ol (10 mmol), iodomethane (20 mmol) and potassium carbonate (20 mmol) were mixed in 100 mL of acetone and the reaction was carried out at reflux overnight. Upon completion of the reaction, the inorganic salts were removed by filtration and the solvent was removed by rotary evaporation. The crude product was purified by column chromatography (eluent ratio ethyl acetate:hexane = 1:5) to give a colorless liquid product [19] in 95% yield. The product characterization data were as follows: 1H NMR (CDCl3) δ 7.74-7.75 (m, 1H, C6-H), 7.26-7.31 (m, 1H, C4-H), 7.11-7.15 (m, 1H, C5-H), 3.91 (s, 3H, OMe); 19F NMR (CDCl3) δ 90.15 (s); ESI-MS: 128 (M + 1)+.
References
[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 11407; 1408
[2] Patent: WO2009/103950, 2009, A1. Location in patent: Page/Page column 15; 16
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2185 - 2195
[4] Journal of Fluorine Chemistry, 2015, vol. 173, p. 29 - 34
[5] Patent: WO2016/89722, 2016, A1. Location in patent: Page/Page column 34