PYRIDINE, 2,6-DIFLUORO-4-IODO-
- Product Name
- PYRIDINE, 2,6-DIFLUORO-4-IODO-
- CAS No.
- 685517-71-9
- Chemical Name
- PYRIDINE, 2,6-DIFLUORO-4-IODO-
- Synonyms
- 2 6-DICHLORO-4-IODOPYRI;2,6-fluoro-4-iodopyridine;4-Iodo-2,6-difluoropyridine;2,6-DIFLUORO-4-IODODPYRIDINE;2,6-difluoro-4- iodo-Pyridine;PYRIDINE, 2,6-DIFLUORO-4-IODO-
- CBNumber
- CB12468476
- Molecular Formula
- C5H2F2IN
- Formula Weight
- 240.98
- MOL File
- 685517-71-9.mol
PYRIDINE, 2,6-DIFLUORO-4-IODO- Property
- Melting point:
- 80-82 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 222.0±35.0 °C(Predicted)
- Density
- 2.129±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -7.48±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C5H2F2IN/c6-4-1-3(8)2-5(7)9-4/h1-2H
- InChIKey
- AXPNCSVJCFXRBC-UHFFFAOYSA-N
- SMILES
- C1(F)=NC(F)=CC(I)=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D448733
- Product name
- 2,6-Difluoro-4-iodopyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 9718AL
- Product name
- 2,6-Difluoro-4-iodopyridine
- Packaging
- 250mg
- Price
- $46
- Updated
- 2021/12/16
- Product number
- 446274
- Product name
- 2,6-Difluoro-4-iodopyridine
- Packaging
- 250mg
- Price
- $22
- Updated
- 2021/12/16
- Product number
- PC502363
- Product name
- 2,6-Difluoro-4-iodopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3H32-K-38
- Product name
- 2,6-Difluoro-4-iodopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
PYRIDINE, 2,6-DIFLUORO-4-IODO- Chemical Properties,Usage,Production
Synthesis
685517-67-3
685517-71-9
The general procedure for the synthesis of 2,6-difluoro-4-iodopyridine from 2,6-difluoro-3-iodopyridine was as follows: n-butyllithium (1.66 mL, 4.15 mmol, 2.5 mol/L hexane solution) was slowly added dropwise to a solution of tetrahydrofuran (THF, 2 mL) with diisopropylamine (1.30 mL, 4.15 mmol) at -78 °C. 25 minutes later, a solution of 2,6-difluoro-3-iodopyridine (1.00 g, 4.15 mmol) in THF (5 mL) was added dropwise to the above mixture via cannula. The reaction mixture was kept at -78 °C for 12 h. THF (2 mL) solution in water (0.2 mL, 11 mmol) was subsequently added and slowly warmed up to room temperature over a period of 1 h. The reaction was carried out at -78 °C for 1 h. The reaction was carried out in a controlled manner. Upon completion of the reaction, the reaction mixture was washed with 10% aqueous Na2SO3 solution (5 mL) and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. The target product 2,6-difluoro-4-iodopyridine was obtained by hexane crystallization as colorless crystals (740 mg, 74% yield). The product was characterized as follows: 1H NMR (400 MHz, CDCl3): δ 7.22 (t, 2H, J = 1.2 Hz); 13C NMR (100 MHz, CDCl3): δ 161.1 (dd, J = 250, 16 Hz, 2C), 115.6 (dd, J = 24, 10 Hz, 2C), 110.3; 19F NMR (376 MHz, CDCl3): δ -68.1; GC-MS m/z: Calculated value 241 [M+], measured value 241; Melting point: 78-80 °C.
References
[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 18, p. 5026 - 5030
[2] Angew. Chem., 2017, vol. 129, p. 5108 - 5112,5
[3] Chinese Chemical Letters, 2017, vol. 28, # 3, p. 525 - 530
[4] Organic Letters, 2007, vol. 9, # 25, p. 5175 - 5178
PYRIDINE, 2,6-DIFLUORO-4-IODO- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PYRIDINE, 2,6-DIFLUORO-4-IODO- manufacturers
- Product
- PYRIDINE, 2,6-DIFLUORO-4-IODO- 685517-71-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19