Pyridine, 2-bromo-5-(bromomethyl)- (9CI)

Product Name: Pyridine, 2-bromo-5-(bromomethyl)- (9CI)
CAS No.: 101990-45-8
Chemical Name: Pyridine, 2-bromo-5-(bromomethyl)- (9CI)
Synonyms: 2-Bromo-5-(bromomethyl)pyridine;2-Bromo-5-(bromomethyl);6-Bromo-3-pyridylmethyl bromide;3-Pyridineacetonitrile, 6-bromo-;2-Bromo-5-(bromomethyl)pyridine 96%;Pyridine, 2-bromo-5-(bromomethyl)- (9CI)
CBNumber: CB31050122
Molecular Formula: C6H5Br2N
Formula Weight: 250.92
MOL File: 101990-45-8.mol

More

Less

Pyridine, 2-bromo-5-(bromomethyl)- (9CI) Property

Melting point:: 60-65°C
Boiling point:: 296.9±25.0 °C(Predicted)
Density: 1.955
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Soluble), Methanol (Slightly)
form: Solid
pka: -0.12±0.10(Predicted)
color: White to Pale Yellow
InChIKey: CRRMIKBAPPOPNW-UHFFFAOYSA-N

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
RIDADR: UN 3335
WGK Germany: 3
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B680748
Product name: 2-Bromo-5-(bromomethyl)pyridine
Packaging: 250mg
Price: $100
Updated: 2021/12/16

TRC

Product number: B680748
Product name: 2-Bromo-5-(bromomethyl)pyridine
Packaging: 1g
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB159610
Product name: 2-Bromo-5-(bromomethyl)pyridine
Packaging: 1g
Price: $245
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB159610
Product name: 2-Bromo-5-(bromomethyl)pyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB159610
Product name: 2-Bromo-5-(bromomethyl)pyridine
Packaging: 250mg
Price: $100
Updated: 2021/12/16

More

Less

Pyridine, 2-bromo-5-(bromomethyl)- (9CI) Chemical Properties,Usage,Production

Uses

2-Bromo-5-(bromomethyl)pyridine is a useful research chemical compound used in the synthesis of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase.

Synthesis

3510-66-5

101990-45-8

General procedure for the synthesis of 2-bromo-5-(bromomethyl)pyridine from 2-bromo-5-methylpyridine: 1. dissolve 12 g (70 mmol) of 2-bromo-5-methylpyridine in 100 mL of 1,2-dichloroethane. 2. 16 g (91 mmol) of N-bromosuccinimide and 0.40 g (2.4 mmol) of 2,2'-azobis(isobutyronitrile) were added to the above solution. 3. The reaction mixture was stirred at 85 °C for 15 min. 4. Upon completion of the reaction, water was added to the reaction mixture and the organic layer was separated. 5. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under vacuum. 6. The resulting residue was purified by silica gel column chromatography with an eluent ratio of solvent-free hexane:ethyl acetate = 10:1 to 9:1 (v/v). 7. The fraction containing the target compound was collected and concentrated in vacuo to give 15 g of 2-bromo-5-(bromomethyl)pyridine as white powder in 89% yield. 8. 8. The Rf value of the product was 0.63 (n-hexane:ethyl acetate=9:1, v/v). 9. Mass spectrum (CI, m/z): 250, 252, 254 (M++1). 10. 10. 1H-NMR spectrum (CDCl3, δ ppm): 4.42 (s, 2H), 7.49 (d, J=8.3 Hz, 1H), 7.61 (dd, J1=8.3 Hz, J2=2.7 Hz, 1H), 8.39 (d, J=2.7 Hz, 1H).

References

[1] Patent: EP1679308, 2006, A1. Location in patent: Page/Page column 35
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 4, p. 1992 - 2010
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 1, p. 2 - 6
[4] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 8, p. 559 - 564
[5] Patent: WO2012/52540, 2012, A1. Location in patent: Page/Page column 47; 48-49

Pyridine, 2-bromo-5-(bromomethyl)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Pyridine, 2-bromo-5-(bromomethyl)- (9CI) Suppliers

China 85 Europe 1 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 10 Global 103

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Amber MolTech LLC

Tel: 086-010-62176588
Fax: 086-010-62117849
Email: amber@jyamber.com
Country: China
ProdList: 10151
Advantage: 56

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 02151602123
Email: sales@cochemical.com
Country: China
ProdList: 3014
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

More

Less

View Lastest Price from Pyridine, 2-bromo-5-(bromomethyl)- (9CI) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Bromo-5-(bromomethyl)pyridine 101990-45-8
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: Pyridine, 2-bromo-5-(bromomethyl)- (9CI) 101990-45-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

101990-45-8, Pyridine, 2-bromo-5-(bromomethyl)- (9CI)Related Search:

Pyridine, 2-chloro-5-iodo-4-methyl- PYRIDINE-4-BORONIC ACID PROPANEDIOL-1,3 CYCLIC ESTER Pyridine, 3-(methylthio)- (6CI,8CI,9CI) Pyridine, 5-bromo-2-ethoxy-4-methyl- (9CI) Pyridine, 2-fluoro-3-(methylthio)- (9CI) PYRIDINE IODINE MONOCHLORIDE COMPLEX Pyridine, 3-bromo-2-chloro-6-(methylthio)- PYRIDINE-3-BORONIC ACID 1,3-PROPANEDIOL CYCLIC ESTER PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)- Pyridine, 2-fluoro-3,5-dimethyl- (9CI) Pyridine 2-fluoro-6-methyl- 5-methanol Pyridine,2-(1-methylethoxy)- Pyridine, 5-bromo-2-ethoxy-3-methyl- (9CI) Pyridine, 2-fluoro-3-methoxy- (9CI) PYRIDINE, 2,6-DIFLUORO-4-IODO- 2,5-Dichloro-4-iodopyridine Pyridine, 3-bromo-6-ethoxy-2-methyl- (9CI) Pyridine,2-chloro-6-(1-methylethoxy)-

Pyridine, 2-bromo-5-(bromomethyl)- (9CI)

2-Bromo-5-(bromomethyl)pyridine

6-Bromo-3-pyridylmethyl bromide

2-Bromo-5-(bromomethyl)pyridine 96%

3-Pyridineacetonitrile, 6-bromo-

2-Bromo-5-(bromomethyl)

101990-45-8

OLED materials,pharm chemical,electronic

PYRIDINE