Pyridine, 2-fluoro-3-methoxy- (9CI)

Product Name: Pyridine, 2-fluoro-3-methoxy- (9CI)
CAS No.: 163234-74-0
Chemical Name: Pyridine, 2-fluoro-3-methoxy- (9CI)
Synonyms: 2-Fluoro-3-methoxypyridine;Pyridine,2-fluoro-3-Methoxy-;Pyridine, 2-fluoro-3-methoxy- (9CI)
CBNumber: CB01047884
Molecular Formula: C6H6FNO
Formula Weight: 127.12
MOL File: 163234-74-0.mol

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Pyridine, 2-fluoro-3-methoxy- (9CI) Property

Boiling point:: 190.8±20.0 °C(Predicted)
Density: 1.146±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.22±0.10(Predicted)
form: liquid
color: Colourless

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: F592333
Product name: 2-Fluoro-3-methoxypyridine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 041230
Product name: 2-Fluoro-3-methoxypyridine
Purity: 98%
Packaging: 1g
Price: $46
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y15200
Product name: 2-Fluoro-3-methoxypyridine
Purity: 98%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: PC908496
Product name: 2-Fluoro-3-methoxypyridine
Purity: 95%
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 041230
Product name: 2-Fluoro-3-methoxypyridine
Purity: 98%
Packaging: 5g
Price: $189
Updated: 2021/12/16

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Pyridine, 2-fluoro-3-methoxy- (9CI) Chemical Properties,Usage,Production

Synthesis

174669-74-0

74-88-4

163234-74-0

Synthesis of 2-fluoro-3-methoxypyridine (3): 2-fluoropyridin-3-ol (10 mmol), iodomethane (20 mmol) and potassium carbonate (20 mmol) were mixed in 100 mL of acetone and the reaction was carried out at reflux overnight. Upon completion of the reaction, the inorganic salts were removed by filtration and the solvent was removed by rotary evaporation. The crude product was purified by column chromatography (eluent ratio ethyl acetate:hexane = 1:5) to give a colorless liquid product [19] in 95% yield. The product characterization data were as follows: 1H NMR (CDCl3) δ 7.74-7.75 (m, 1H, C6-H), 7.26-7.31 (m, 1H, C4-H), 7.11-7.15 (m, 1H, C5-H), 3.91 (s, 3H, OMe); 19F NMR (CDCl3) δ 90.15 (s); ESI-MS: 128 (M + 1)+.

References

[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 11407; 1408
[2] Patent: WO2009/103950, 2009, A1. Location in patent: Page/Page column 15; 16
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2185 - 2195
[4] Journal of Fluorine Chemistry, 2015, vol. 173, p. 29 - 34
[5] Patent: WO2016/89722, 2016, A1. Location in patent: Page/Page column 34

Pyridine, 2-fluoro-3-methoxy- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridine, 2-fluoro-3-methoxy- (9CI) Suppliers

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