Pyridine, 2-chloro-5-iodo-4-methyl-
- Product Name
- Pyridine, 2-chloro-5-iodo-4-methyl-
- CAS No.
- 550347-54-1
- Chemical Name
- Pyridine, 2-chloro-5-iodo-4-methyl-
- Synonyms
- 2-Chloro-5-iodo-4-methylpyridine;2-Fluor-3-iod-6-methylpyridin;2-Chloro-4-methyl-5-iodopyridine;Pyridine, 2-chloro-5-iodo-4-methyl-;Pyridine, 2-chloro-5-iodo-4-methyl- ISO 9001：2015 REACH
- CBNumber
- CB52456684
- Molecular Formula
- C6H5ClIN
- Formula Weight
- 253.47
- MOL File
- 550347-54-1.mol
Pyridine, 2-chloro-5-iodo-4-methyl- Property
- Boiling point:
- 279.4±35.0 °C(Predicted)
- Density
- 1.906±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.20±0.10(Predicted)
- Appearance
- Colorless to light yellow Solid-liquid mixture
- InChI
- InChI=1S/C6H5ClIN/c1-4-2-6(7)9-3-5(4)8/h2-3H,1H3
- InChIKey
- GGKYISVMVRLEDY-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(I)C(C)=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C367298
- Product name
- 2-Chloro-5-iodo-4-methylpyridine
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR948230
- Product name
- 2-Chloro-5-iodo-4-methylpyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC32459
- Product name
- 2-Chloro-5-iodo-4-methylpyridine
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 3H32-M-0H
- Product name
- 2-Chloro-5-iodo-4-methylpyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- FC32459
- Product name
- 2-Chloro-5-iodo-4-methylpyridine
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
Pyridine, 2-chloro-5-iodo-4-methyl- Chemical Properties,Usage,Production
Uses
2-Chloro-5-iodo-4-methylpyridine can be used as reactant/reagent of synthesis of conformationally constrained spirodihydrofuropyridine analogs of epibatidine.
Synthesis
356561-08-5
550347-54-1
The general procedure for the synthesis of 2-chloro-4-methyl-5-iodopyridine from 2-amino-5-iodo-4-methylpyridine was as follows: to a stirred solution of concentrated hydrochloric acid (233 mL) at 0 °C was added 5-iodo-4-methylpyridin-2-ylamine (25 g, 107 mmol, 1 eq.), followed by sodium nitrite (29.5 g, 427 mmol, 4 eq.), which had been pre-dissolved in water (100 mL). 427 mmol, 4 eq.), and the titration process was controlled to be completed within 30 min. The reaction mixture was stirred at room temperature for 16 hours. After confirming complete consumption of the feedstock by TLC monitoring, the reaction mixture was cooled to 0 °C and the pH was adjusted to 12 with saturated aqueous sodium hydroxide solution. the reaction mixture was extracted with dichloromethane (3 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a brown oily crude product (23 g). The crude product was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution of 4% ethyl acetate as eluent.The fraction containing the target compound was collected and concentrated under reduced pressure to give 2-chloro-4-methyl-5-iodopyridine as a brown oil (8 g, 30% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.38 (s, 3H), 7.21 (s, 1H), 8.59 (s, 1H).LC-MS (m/z): 253.7 (M + H).
References
[1] Tetrahedron Letters, 2003, vol. 44, # 14, p. 2971 - 2973
[2] Patent: WO2014/39484, 2014, A1. Location in patent: Page/Page column 61
Pyridine, 2-chloro-5-iodo-4-methyl- Preparation Products And Raw materials
Raw materials
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View Lastest Price from Pyridine, 2-chloro-5-iodo-4-methyl- manufacturers
- Product
- 2-Fluor-3-iod-6-methylpyridin 550347-54-1
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- Pyridine, 2-chloro-5-iodo-4-methyl- 550347-54-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-02
- Product
- Pyridine, 2-chloro-5-iodo-4-methyl- 550347-54-1
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20