2-Benzyl-2-thiopseudourea hydrochloride

Product Name: 2-Benzyl-2-thiopseudourea hydrochloride
CAS No.: 538-28-3
Chemical Name: 2-Benzyl-2-thiopseudourea hydrochloride
Synonyms: SBT;btkh;tl944;NSC3206;U-19451A;usafek-2124;WLN: MUYZS1R &GH;2-BENZYL-ISOTHIOUREA;Benzylthiuronium salt;benzyl Isothiourea HCl
CBNumber: CB0104986
Molecular Formula: C8H11ClN2S
Formula Weight: 202.7
MOL File: 538-28-3.mol

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2-Benzyl-2-thiopseudourea hydrochloride Property

Melting point:: 172-177 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: methanol: soluble1g/10 mL, clear, colorless to very faintly yellow
form: powder to crystal
color: White
Water Solubility: 250 g/L (15 ºC)
Sensitive: Hygroscopic
Merck: 14,1146
BRN: 3656719
InChI: InChI=1S/C8H10N2S.ClH/c9-8(10)11-6-7-4-2-1-3-5-7;/h1-5H,6H2,(H3,9,10);1H
InChIKey: WJAASTDRAAMYNK-UHFFFAOYSA-N
SMILES: C1(C=CC=CC=1)CSC(=N)N.Cl
CAS DataBase Reference: 538-28-3(CAS DataBase Reference)
EPA Substance Registry System: Carbamimidothioic acid, phenylmethyl ester, monohydrochloride (538-28-3)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36/37/39-45-28A
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: UM0738000
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29309070
Toxicity: LD50 oral in rat: 27mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 251038
Product name: 2-Benzyl-2-thiopseudourea hydrochloride
Purity: 98%
Packaging: 100g
Price: $118
Updated: 2025/07/31

TCI Chemical

Product number: B0442
Product name: S-Benzylisothiourea Hydrochloride
Purity: >99.0%(T)
Packaging: 25g
Price: $168
Updated: 2025/07/31

TRC

Product number: B315165
Product name: 2-Benzyl-2-thiopseudourea hydrochloride
Packaging: 5g
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK106332
Product name: 2-Benzyl-2-thiopseudourea hydrochloride
Purity: 98%
Packaging: 25g
Price: $37
Updated: 2021/12/16

Oakwood

Product number: 099378
Product name: S-Benzylisothiourea Hydrochloride
Purity: 97%
Packaging: 5g
Price: $90
Updated: 2021/12/16

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2-Benzyl-2-thiopseudourea hydrochloride Chemical Properties,Usage,Production

Chemical Properties

off-white to light beige crystalline powder

Uses

Reagent for cobalt and nickel; identification and separation of carboxylic, sulfinic, and sulfonic acid.

General Description

S-benzylisothiourea analogs (2-benzyl-2-thiopseudourea hydrochloride), as small-molecule inhibitors of indoleamine-2,3-dioxygenase, has been studied.

Safety Profile

Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits very toxic fumesof HCl, SOx, and NOx.

Synthesis

100-44-7

17356-08-0

538-28-3

GENERAL METHOD: Benzyl chloride (3 mmol) was dissolved with thiourea (3 mmol) in anhydrous ethanol (2 mL) and the reaction was refluxed at 95°C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and stirring was continued for 12 hours. The resulting precipitate was collected by filtration and washed with cold anhydrous ethanol to give the final S-benzylthiourea hydrochloride.

Purification Methods

Crystallise the chloride from 0.2M HCl (2mL/g) or EtOH and it dry in air. [Beilstein 6 III 1600.]

References

[1] Analytical Chemistry, 1987, vol. 59, # 4, p. 562 - 567
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 8, p. 2426 - 2431
[3] Journal of Pharmaceutical Sciences, 1984, vol. 73, # 3, p. 374 - 377
[4] European Journal of Organic Chemistry, 2002, # 7, p. 1163 - 1174
[5] Chemische Berichte, 1879, vol. 12, p. 575

2-Benzyl-2-thiopseudourea hydrochloride Preparation Products And Raw materials

Raw materials

Benzyl chloride

Preparation Products

Benzyl mercaptan o-methoxycarbonyl benzyl sulfonyl chloride

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2-Benzyl-2-thiopseudourea hydrochloride Suppliers

Americas 1 Belgium 1 China 119 China Hong Kong 1 Europe 1 France 1 Germany 3 India 13 Japan 1 Switzerland 2 United Kingdom 6 United States 24 Global 173

Shanghai Hansi Chemical Industry Co., Ltd.

Tel: 17717618050
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Syntechem Co.,Ltd

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Sichuan Kulinan Technology Co., Ltd

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View Lastest Price from 2-Benzyl-2-thiopseudourea hydrochloride manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 2-Benzyl-2-thiopseudourea hydrochloride 538-28-3
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-08-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Benzyl-2-thiopseudourea hydrochloride 538-28-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: S-Benzylisothiourea Hydrochloride 538-28-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

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Building Blocks

Organic Building Blocks

Sulfur Compounds

Thioureas

Building Blocks

Chemical Synthesis