Lusvertikimab

Product Name: Lusvertikimab
CAS No.: 2375835-91-7
Chemical Name: Lusvertikimab
Synonyms: Lusvertikimab;Lusvertikimab (anti-CD127);Research Grade Lusvertikimab;Research Grade Lusvertikimab (DHD19401)
CBNumber: CB010617047
Formula Weight: 0
MOL File: Mol file

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Lusvertikimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Lusvertikimab Chemical Properties,Usage,Production

Uses

Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research[1].

in vivo

OSE-127 treated mice shows a reduction of peripheral blood (PB) blasts in 21/22 (95%) PDX samples in vivo when the corresponding control mice showed clinical signs of overt leukemia^[1].

IC 50

IL7R

References

[1] Lennart Lenk, et al. The IL7R-Antagonist OSE-127 Blocks Acute Lymphoblastic Leukemia Development Via a Dual Mode of Action. ACUTE LYMPHOBLASTIC LEUKEMIAS: BIOMARKERS, MOLECULAR MARKERS AND MINIMAL RESIDUAL DISEASE IN DIAGNOSIS AND PROGNOSIS| NOVEMBER 15, 2022.
[2] Elodie Rivière,, et al. Interleukin-7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sj?gren's Syndrome. Arthritis Rheumatol. 2021 Apr;73(4):631-640. DOI:10.1002/art.41558

Lusvertikimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Lusvertikimab Suppliers

China 13 United States 1 Global 14

Shanghai YuanYe Biotechnology Co., Ltd.

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Guangzhou Hongyuan Chemical Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Biolab Reagents

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Shanghai Yifei Biotechnology Co. , Ltd.

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Wanxin Biotechnology (Jiaxing) Co., LTD

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Atagenix Laboratories

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AntibodySystem Laboratories SAS

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2375835-91-7, LusvertikimabRelated Search:

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Lusvertikimab

Research Grade Lusvertikimab (DHD19401)

Research Grade Lusvertikimab

Lusvertikimab (anti-CD127)

2375835-91-7