Lirentelimab
- Product Name
- Lirentelimab
- CAS No.
- 2283348-97-8
- Chemical Name
- Lirentelimab
- Synonyms
- Lirentelimab;Research Grade Lirentelimab;Lirentelimab (anti-Siglec-8);Research Grade Lirentelimab (DHK16101)
- CBNumber
- CB012204966
- Formula Weight
- 0
- MOL File
- Mol file
Lirentelimab Property
- form
- Liquid
- color
- Colorless to light yellow
Lirentelimab Chemical Properties,Usage,Production
Uses
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis[1].
in vivo
Lirentelimab (100 μg; i.v. once) significantly inhibits IgE-mediated mast cell activation in a mice model of systemic anaphylaxis[1].
| Animal Model: | Humanized mice (NSG-SGM3) engrafts with human thymus, liver, and HSC[1] |
| Dosage: | 100 μg |
| Administration: | Intravenous injection; 100 μg, once |
| Result: | Completely prevented passive systemic anaphylaxis (PSA) as shown by a lack of change in rectal temperature and symptom scores in mice. |
References
[1] Youngblood BA, et al. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019;180(2):91-102. DOI:10.1159/000501637
Lirentelimab Preparation Products And Raw materials
Raw materials
Preparation Products
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