Emicizumab

Product Name: Emicizumab
CAS No.: 1610943-06-0
Chemical Name: Emicizumab
Synonyms: Emicizumab;ACE 910|||RO 5534262;Research Grade Emicizumab;Emicizumab (anti-Factor IX);Research Grade Emicizumab (DHB87901)
CBNumber: CB93339870
Formula Weight: 0
MOL File: Mol file

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Emicizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Emicizumab Chemical Properties,Usage,Production

Uses

Emicizumab is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. Emicizumab can be used for hemophilia A research[1].

in vivo

Emicizumab (1.5-10 mg/kg, IV, 24 hours before tail-clip bleeding) partially corrects blood loss in a hemophilia A bleeding model, with an FVIII equivalence of 9 U/dL^[1].
Emicizumab (3 mg/kg, IV) provides additive hemostatic activity when given in combination with low-dose FVIII (10 U/dL)^[1].

Animal Model:	FVIII-deficient mice^[1]
Dosage:	1.5-10 mg/kg
Administration:	IV, 24 hours before tail-clip bleeding was performed
Result:	Significantly reduced blood loss in a tail-clip-bleeding model using FVIII-deficient mice.

References

[1] Ferrière S, et al. A hemophilia A mouse model for the in vivo assessment of emicizumab function. Blood. 2020 Aug 6;136(6):740-748. DOI:10.1182/blood.2019004334

Emicizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Emicizumab Suppliers

China 30 United States 2 Global 32

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1610943-06-0, EmicizumabRelated Search:

Tosatoxumab Azintuxizumab Amubarvimab Bapotulimab Atidortoxumab Ociperlimab Relfovetmab Coltuximab Ravtansine Research Grade Imdevimab (DVV00305) Tibulizumab

Emicizumab

Research Grade Emicizumab (DHB87901)

Emicizumab (anti-Factor IX)

ACE 910|||RO 5534262

Research Grade Emicizumab

1610943-06-0