ChemicalBook > CAS DataBase List > Emicizumab
Emicizumab
- Product Name
- Emicizumab
- CAS No.
- 1610943-06-0
- Chemical Name
- Emicizumab
- Synonyms
- Emicizumab;ACE 910|||RO 5534262;Research Grade Emicizumab;Emicizumab (anti-Factor IX);Research Grade Emicizumab (DHB87901)
- CBNumber
- CB93339870
- Formula Weight
- 0
- MOL File
- Mol file
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Emicizumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Emicizumab Chemical Properties,Usage,Production
Uses
Emicizumab is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. Emicizumab can be used for hemophilia A research[1].
in vivo
Emicizumab (1.5-10 mg/kg, IV, 24 hours before tail-clip bleeding) partially corrects blood loss in a hemophilia A bleeding model, with an FVIII equivalence of 9 U/dL[1].
Emicizumab (3 mg/kg, IV) provides additive hemostatic activity when given in combination with low-dose FVIII (10 U/dL)[1].
| Animal Model: | FVIII-deficient mice[1] |
| Dosage: | 1.5-10 mg/kg |
| Administration: | IV, 24 hours before tail-clip bleeding was performed |
| Result: | Significantly reduced blood loss in a tail-clip-bleeding model using FVIII-deficient mice. |
References
[1] Ferrière S, et al. A hemophilia A mouse model for the in vivo assessment of emicizumab function. Blood. 2020 Aug 6;136(6):740-748. DOI:10.1182/blood.2019004334
Emicizumab Preparation Products And Raw materials
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