Lusvertikimab
- Product Name
- Lusvertikimab
- CAS No.
- 2375835-91-7
- Chemical Name
- Lusvertikimab
- Synonyms
- Lusvertikimab;Lusvertikimab (anti-CD127);Research Grade Lusvertikimab;Research Grade Lusvertikimab (DHD19401)
- CBNumber
- CB010617047
- Formula Weight
- 0
- MOL File
- Mol file
Lusvertikimab Property
- form
- Liquid
- color
- Colorless to light yellow
Lusvertikimab Chemical Properties,Usage,Production
Uses
Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research[1].
in vivo
OSE-127 treated mice shows a reduction of peripheral blood (PB) blasts in 21/22 (95%) PDX samples in vivo when the corresponding control mice showed clinical signs of overt leukemia[1].
IC 50
IL7R
References
[1] Lennart Lenk, et al. The IL7R-Antagonist OSE-127 Blocks Acute Lymphoblastic Leukemia Development Via a Dual Mode of Action. ACUTE LYMPHOBLASTIC LEUKEMIAS: BIOMARKERS, MOLECULAR MARKERS AND MINIMAL RESIDUAL DISEASE IN DIAGNOSIS AND PROGNOSIS| NOVEMBER 15, 2022.
[2] Elodie Rivière,, et al. Interleukin-7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sj?gren's Syndrome. Arthritis Rheumatol. 2021 Apr;73(4):631-640. DOI:10.1002/art.41558
Lusvertikimab Preparation Products And Raw materials
Raw materials
Preparation Products
Lusvertikimab Suppliers
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19961
- Advantage
- 58