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Rituximab

Product Name
Rituximab
CAS No.
174722-31-7
Chemical Name
Rituximab
Synonyms
Retuxin;Rituxan;Mabthera;Mab thera;Hsdb 7455;Rituximab;Unii-4F4X42syq6;Immunoglobulin G1;Rituximab 13mg/ml;Rituximab USP/EP/BP
CBNumber
CB01074099
Molecular Formula
C6416H9874N1688O1987S44
Formula Weight
0
MOL File
Mol file
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Rituximab Property

storage temp. 
Store at -80°C
form 
Liquid
color 
Colorless to light yellow
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Safety

Hazardous Substances Data
174722-31-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1445539
Product name
USP mAb 001, Monoclonal IgG1
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
2MG
Price
$1370
Updated
2024/03/01
Usbiological
Product number
366145
Product name
Immunoglobulin G1
Packaging
96Tests
Price
$809
Updated
2021/12/16
Usbiological
Product number
152699
Product name
Immunoglobulin G1
Packaging
96Tests
Price
$851
Updated
2021/12/16
Biosynth Carbosynth
Product number
BR167936
Product name
Rituximab - 10mg/ml solution
Packaging
1mg
Price
$350
Updated
2021/12/16
Biosynth Carbosynth
Product number
BR167936
Product name
Rituximab - 10mg/ml solution
Packaging
2mg
Price
$500
Updated
2021/12/16
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Rituximab Chemical Properties,Usage,Production

Description

Rituximab, a chimeric murine/human monoclonal antibody approved in the United States only for treating refractory or relapsed B-cell lymphomas, reacts with the CD20 antigen. It contains the complementarity determining murine anti-CD20 antibody 2B8 regions in conjunction with human kappa and IgG1 heavy-chain constant region sequences. The vector was cloned into Chinese hamster ovarian cells as the production source of immunoglobulin. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids with a molecular weight of 145 kD. Rituximab has a binding affinity for the CD20 antigen of approximately 8.0 nM, similar to the parent murine antibody, 2B8[1].

Uses

Antineoplastic (microtubule inhibitor); monoclonal antibody.

Uses

Rituximab is being used for Coronavirus-related infections.

brand name

Rituxan (IDEC).

Mechanism of action

Rituximab has a unique mode of action and can induce the killing of CD20+ cells via multiple mechanisms. The direct effects of rituximab include complement-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity, and the indirect effects include structural changes, apoptosis, and sensitization of cancer cells to chemotherapy.

Clinical Use

Rituximab has seen use in transplant patients in several settings: (1) treatment of post-transplant lymphoproliferative disease (PTLD); (2) prevention of rejection; (3) ABO-incompatible transplantation; (4) treatment of rejection; (5) desensitization in HLA sensitized patients. The treatment of post-transplant lymphoproliferative disease has probably seen the greatest use of rituximab with great success. However, there is no formal indication of this use. In non-transplant patients with lymphoma, rituximab is typically combined with other chemotherapeutic agents with somewhat worse results.

Rituximab Preparation Products And Raw materials

Raw materials

Preparation Products

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Rituximab Suppliers

Hubei Zhongshan Medical Technology Co., Ltd
Tel
027-61907345 13397111514
Fax
3443707954
Email
w13397111514@163.com
Country
China
ProdList
1010
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Wuhan Sunrise Technology Development Co., Ltd.
Tel
27-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
249
Advantage
62
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2872
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
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View Lastest Price from Rituximab manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Rituximab 174722-31-7
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-08
Dideu Industries Group Limited
Product
Rituximab 174722-31-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Rituximab 174722-31-7
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

174722-31-7, RituximabRelated Search:


  • IMMunoglobulin G1,anti-(huMan CD20 (antigen)) (huMan-Mouse Monoclonal IDEC-C2B8 g1-chain), disulfide withhuMan-Mouse Monoclonal IDEC-C2B8 k-chain, diMer
  • Ig gamma-1 chain C region
  • Immunoglobulin G1
  • Hsdb 7455
  • Immunoglobulin G 1 (human-mouse monoclonal idec-C2B8 gamma1-chain anti-human antigen cd 20), disulfide with human-mouse monoclonal idec-C2B8 kappa-chain, dimer
  • Mab thera
  • Mabthera
  • Rituxan
  • Unii-4F4X42syq6
  • Retuxin
  • Rituximab - 10mg/ml solution
  • Rituximab (anti-CD20)
  • Rituximab USP/EP/BP
  • Rituximab 13mg/ml
  • Rituximab,174722-31-7
  • Research Grade Rituximab(DHC90705)
  • USP mAb 001, Monoclonal IgG1 (2 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
  • Rituximab
  • 174722-31-7
  • C6416H9874N1688O1987S44