2-Amino-4-methoxypyrimidine

Product Name: 2-Amino-4-methoxypyrimidine
CAS No.: 155-90-8
Chemical Name: 2-Amino-4-methoxypyrimidine
Synonyms: 2-AMino-4-Methoxy-pyriMidin;2-AMINO-4-METHOXYPYRIMIDINE;4-methoxy-2-aminopyrimidine;2-Methoxy-4-aMinopyriMidine;2-Pyrimidinamine, 4-methoxy-;2-Methoxy-4-aminopyrimidi...;2-Pyrimidinamine, 4-methoxy- (9CI);2-Pyrimidinamine, 4-methoxy- (9CI) ISO 9001：2015 REACH;4-Methoxypyrimidin-2-amine, 4-Methoxy-1,3-diazin-2-amine
CBNumber: CB01081314
Molecular Formula: C5H7N3O
Formula Weight: 125.13
MOL File: 155-90-8.mol

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2-Amino-4-methoxypyrimidine Property

Melting point:: 119-120 °C
Boiling point:: 313.1±34.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 5?+-.0.10(Predicted)
color: Pale yellow
InChI: InChI=1S/C5H7N3O/c1-9-4-2-3-7-5(6)8-4/h2-3H,1H3,(H2,6,7,8)
InChIKey: YNXLSFXQTQKQEF-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(OC)=N1

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Safety

HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

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N-Bromosuccinimide Price

TRC

Product number: M226528
Product name: 4-Methoxypyrimidin-2-amine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-WA
Product name: 2-Amino-4-methoxypyrimidine
Packaging: 1g
Price: $56
Updated: 2021/12/16

Matrix Scientific

Product number: 068422
Product name: 4-Methoxypyrimidin-2-amine
Purity: >95%
Packaging: 1g
Price: $98
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: CAPOA12242
Product name: 2-Amino-4-methoxypyrimidine
Purity: 97%
Packaging: 1g
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-WA
Product name: 2-Amino-4-methoxypyrimidine
Packaging: 5G
Price: $196
Updated: 2021/12/16

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2-Amino-4-methoxypyrimidine Chemical Properties,Usage,Production

Synthesis

5734-64-5

155-90-8

General procedure for the synthesis of 2-amino-4-methoxypyrimidine from 4-chloro-6-methoxypyrimidin-2-amine: 4-chloro-6-methoxypyrimidin-2-amine (2.00 g, 12.58 mmol) was dissolved in a solvent mixture of ethanol and ethyl acetate (1:1.3, v/v), followed by the addition of N,N-diisopropylethylamine (4.35 mL, 25.2 mmol) and a 10% palladium-carbon catalyst (10 mol%). The reaction mixture was stirred for 14 hours under a hydrogen atmosphere (using a hydrogen balloon to maintain positive hydrogen pressure). The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent ratio 1:1 hexane to ethyl acetate). Upon completion of the reaction, the reaction mixture was flushed with nitrogen and filtered through a bed of diatomaceous earth to remove the palladium-carbon catalyst. The diatomaceous earth bed was washed well with ethyl acetate. The filtrates were combined and dried with anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure to give 2-amino-4-methoxypyrimidine as pure product (94% yield). The product did not require further purification and could be used directly in the subsequent reaction.

References

[1] Patent: WO2009/93981, 2009, A1. Location in patent: Page/Page column 104
[2] Patent: WO2008/98058, 2008, A1. Location in patent: Page/Page column 65
[3] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 98-99
[4] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 10, p. 774 - 779
[5] Chemische Berichte, 1903, vol. 36, p. 3383

2-Amino-4-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-methoxypyrimidine Suppliers

China 125 Europe 1 India 2 Ukraine 1 United Kingdom 3 United States 14 Global 146

Pure Chemistry Scientific Inc.

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View Lastest Price from 2-Amino-4-methoxypyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Pyrimidinamine, 4-methoxy- (9CI) 155-90-8
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-12

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Pyrimidinamine, 4-methoxy- (9CI) 155-90-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Jiangsu Liyang Kunlun Biological Technology Co., Ltd.

Product: 2-Amino-4-methoxypyrimidine 155-90-8
Price: US $0.00/kg
Min. Order: 200kg
Purity: ≥99%
Supply Ability: 20 tons
Release date: 2025-04-07

155-90-8, 2-Amino-4-methoxypyrimidineRelated Search:

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2-Pyrimidinamine, 4-methoxy- (9CI)

4-methoxy-2-aminopyrimidine

2-Methoxy-4-aminopyrimidi...

2-Methoxy-4-aMinopyriMidine

4-Methoxypyrimidin-2-amine, 4-Methoxy-1,3-diazin-2-amine

2-AMino-4-Methoxy-pyriMidin

2-Pyrimidinamine, 4-methoxy-

2-Pyrimidinamine, 4-methoxy- (9CI) ISO 9001：2015 REACH

2-AMINO-4-METHOXYPYRIMIDINE

155-90-8

1455-90-8

Amines

PYRIMIDINE

Heterocycle-Pyrimidine series

Imidazoles & Benzimidazoles

Pyrazines, Pyrimidines & Pyridazines