Sulfadimethoxine
Brand Name(s) in US- Product Name
- Sulfadimethoxine
- CAS No.
- 122-11-2
- Chemical Name
- Sulfadimethoxine
- Synonyms
- SULPHADIMETHOXINE;Sulfadimethoxine base;sulfadimethoxin;symbio;sulfadimetoxin;abcid;albon;fuxal;sudine;Dosmin
- CBNumber
- CB7333026
- Molecular Formula
- C12H14N4O4S
- Formula Weight
- 310.33
- MOL File
- 122-11-2.mol
Sulfadimethoxine Property
- Melting point:
- 200 °C
- Boiling point:
- 265.5°C (rough estimate)
- Density
- 1.4006 (rough estimate)
- refractive index
- 1.6270 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- NH4OH 1 M: 50 mg/mL, clear, faintly yellow
- pka
- pKa 5.94(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
- color
- White to Off-White
- Water Solubility
- 46.3mg/L(37 ºC)
- Merck
- 14,8905
- BRN
- 306856
- CAS DataBase Reference
- 122-11-2(CAS DataBase Reference)
- EPA Substance Registry System
- Sulfadimethoxine (122-11-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37-24/25-23
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- WO9030000
- F
- 8
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29350090
- Toxicity
- LD50 orally in mice: >10 g/kg (Seki)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR1448
- Product name
- Sulfadimethoxine
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 1626001
- Product name
- Sulfadimethoxine
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $228.6
- Updated
- 2024/03/01
- Product number
- S0359
- Product name
- Sulfadimethoxine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 28827
- Product name
- Sulfadimethoxine
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 28827
- Product name
- Sulfadimethoxine
- Packaging
- 50g
- Price
- $109
- Updated
- 2024/03/01
Sulfadimethoxine Chemical Properties,Usage,Production
Brand Name(s) in US
Albon, Bactrovet, and generic
Chemical Properties
White Solid
Originator
Madribon,Roche,US,1958
Uses
Antibacterial.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Manufacturing Process
1.4 g of 4-phenylsulfonyl-2,6-dimethoxypyrimidine and 4 g of sodium sulfanilamide (both dried over potassium hydroxide) were very finely ground and heated in an oil bath for 10 hours at 120°C (inside temperature). The reaction mixture was taken up in 30 ml of water and treated with 3 ml of 2 N sodium hydroxide solution. After standing for one hour at 0°C, the turbid solution was filtered and the filtrate was made alkaline with sodium carbonate. After again standing for one hour at 0°C, the precipitate was filtered off (1.9 g of regenerated sulfanilamide) and the filtrate was neutralized with acetic acid, whereupon crystallization resulted. The isolated crystals of 4-sulfanilamido- 2,6-dimethoxypyrimidine weighed 1.3 g (84% of theory), melting point 190°C to 196°C.
Therapeutic Function
Antibacterial
Pharmaceutical Applications
2,4-Dimethoxy-6-sulfanilamido-1,3-diazine. A rapidly absorbed compound with a long half-life (38–40 h) and a high degree of protein binding (98%). Renal clearance is very slow, and daily dosage maintains adequate plasma levels.
Safety Profile
Moderately toxic by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Veterinary Drugs and Treatments
Sulfadimethoxine injection and tablets are approved for use in dogs
and cats for respiratory, genitourinary, enteric and soft tissue infections
caused by susceptible organisms. Sulfadimethoxine is used in
the treatment of coccidiosis in dogs although not approved for this
indication.
In horses, sulfadimethoxine injection is approved for the treatment
of respiratory infections caused by Streptococcus equi.
In cattle, the drug is approved for treating shipping fever complex,
calf diphtheria, bacterial pneumonia and foot rot caused by
susceptible organisms.
In poultry, sulfadimethoxine is added to drinking water to treat
coccidiosis, fowl cholera, and infectious coryza.
Sulfadimethoxine Preparation Products And Raw materials
Raw materials
Preparation Products
Sulfadimethoxine Suppliers
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View Lastest Price from Sulfadimethoxine manufacturers
- Product
- Sulfadimethoxine base 122-11-2
- Price
- US $0.00/kg
- Min. Order
- 100kg
- Purity
- 98%-102; USP40
- Supply Ability
- 5 tons
- Release date
- 2022-05-07
- Product
- Sulfadimethoxine 122-11-2
- Price
- US $80.00/KG
- Min. Order
- 1KG
- Purity
- >99%
- Supply Ability
- 20tons
- Release date
- 2023-03-15
- Product
- Sulfadimethoxine 122-11-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%;USP/EP/CP
- Supply Ability
- 1-10000kgs
- Release date
- 2023-06-27