Sulfalen
- Product Name
- Sulfalen
- CAS No.
- 152-47-6
- Chemical Name
- Sulfalen
- Synonyms
- smp2;Vetkel;longum;as18908;dalysep;sulfalen;f.i.5978;kelfizin;Policydal;SULFALENE
- CBNumber
- CB3725126
- Molecular Formula
- C11H12N4O3S
- Formula Weight
- 280.3
- MOL File
- 152-47-6.mol
Sulfalen Property
- Melting point:
- 176°
- Boiling point:
- 488.6±55.0 °C(Predicted)
- Density
- 1.3936 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, heated)
- form
- Solid
- pka
- pKa 6.20(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
- color
- White to Yellow
- λmax
- 250nm(NaOH aq.)(lit.)
- Merck
- 14,8910
- CAS DataBase Reference
- 152-47-6(CAS DataBase Reference)
Safety
- RTECS
- WP0175000
- HS Code
- 2935.90.9500
- HazardClass
- IRRITANT
- Toxicity
- LD50 in mice (g/kg): 2.164 orally; 1.41 i.v. (US 3098069)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S0917
- Product name
- Sulfalene
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $114
- Updated
- 2024/03/01
- Product number
- S0917
- Product name
- Sulfalene
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $286
- Updated
- 2024/03/01
- Product number
- S699230
- Product name
- Sulfamethoxypyrazine
- Packaging
- 250mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- CS-8165
- Product name
- Sulfalene
- Purity
- 99.90%
- Packaging
- 50mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- API0004273
- Product name
- SULFAMETHOXYPYRAZINE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $401.16
- Updated
- 2021/12/16
Sulfalen Chemical Properties,Usage,Production
Chemical Properties
White to Yellow Solid
Originator
Longum,Farmitalia,W. Germany,1962
Uses
A possible antimalarial drug.
Definition
ChEBI: Sulfamethopyrazine is a member of pyrazines, a sulfonamide and a sulfonamide antibiotic.
Manufacturing Process
2-Amino-3,5-Dibromo-Pyrazine: 112.7 ml of bromine in 375 ml of acetic acid
are slowly added at 0° to +2°C, while stirring, to a solution of 95.11 grams of
2-amino-pyrazine and 326.5 grams of acetic acid trihydrate (CH3COONa·3H2O)
in 1,480 ml of acetic acid. This addition requires about 2 to 3 hours and it is
carried out in the dark. The mixture is then allowed to stand at room
temperature (25° to 30°C) for 15 to 16 hours. About 1.5 liters of acetic acid
are distilled off under vacuum (12 to 14 mm Hg) at 35°C and the brown and
viscous residue is poured into 500 grams of ice-water under stirring.
Aqueous 20% sodium hydroxide is added in order to obtain a pH = 8 and then
the product is filtered and air-dried. The air-dried product is extracted 6 times
with 150 ml of ether; the filtered ethereal solutions are evaporated to dryness
and the residue (50 to 52 grams) is crystallized from hot water. The yield is
34.36 grams, melting at 114°C.
2-Amino-3-Methoxy-5-Bromo-Pyrazine: 7 grams of 2-amino-3,5-dibromopyrazine
are boiled for 9 hours in a methanolic solution of sodium methylate
(obtained from 0.65 gram of Na and 18.5 ml of methanol). By cooling a
crystalline product is obtained, filtered and washed once with methanol and 2
to 3 times with water. The yield is 5.4 grams, melting at 138°C.
2-Amino-3-Methoxy-Pyrazine: 3 grams of 2-amino-3-methoxy-5-bromopyrazine
are hydrogenated, in methanolic solution at room temperature and at
atmospheric pressure, in the presence of 1 gram of palladium over charcoal (10%) and 0.9 gram of potassium hydroxide. When the stoichiometric amount
of hydrogen is absorbed, the suspension is filtered and the filtrate is
evaporated to dryness. The residue is extracted with acetone, the acetonic
solution is evaporated and the residue (1.8 grams, melting at 75° to 82°C) is
crystallized from cyclohexane. The yield is 1.5 grams, melting at 85°C.
2-(p-Acetylaminobenzene-sulfonamido)-3-Methoxy-Pyrazine: 1.5 grams of 2-
amino-3-methoxy-pyrazine dissolved in 15 ml of anhydrous pyridine are
treated, under cooling and stirring, with 2.81 grams of pacetylaminobenzenesulfonyl
chloride, at small portions in about 30 minutes.
The mixture is allowed to stand for 20 hours at room temperature and then is
heated to 50°C for 4 hours.
The solution is concentrated to one-third of its volume, under vacuum, and
poured into ice-water under stirring. The precipitate is filtered and washed
with water. 2.21 grams melting at 218° to 220°C are obtained. The MP
(crystallized from alcohol) is 224°C.
2-Sulfanilamido-3-Methoxy-Pyrazine: 1.5 grams of the product from the
preceding step and 7 to 8 ml of aqueous 10% sodium hydroxide are boiled for
1 hour. The cooled solution is slightly acidified to pH 6 with aqueous 2 N
hydrochloric acid and the product is filtered. The yield is 1.25 grams, melting
at 175°C.
brand name
Kelfizina (Abbott).
Therapeutic Function
Antibacterial
Pharmaceutical Applications
2-Sulfanilamido-3-methoxypyrazine. A very long-acting compound (plasma half-life 60 h). Adequate blood levels can be maintained by giving a dose of 2 g once weekly. The protein binding is c. 70%. It has been successfully used in the single-dose treatment of urinary tract infection. As with other long-acting compounds, sulfametopyrazine has been associated with an increased incidence of erythema multiforme.
Synthesis
Sulfalene, 3-methoxy-2-sulfanilamidopyrazine (33.1.41), like other sulfanilamides, is synthesized by the standard scheme from 4-acetylaminobenzenesulfonyl chloride,
which is reacted with 3-amino-2-methoxypyrazine, which is synthesized by two technologically available methods. The first of these methods consists of direct bromination of 2-aminopyrazine using acetic acid as a solvent, which gives 3,5-dibromo-2-aminopyrazine (33.1.34).
Reacting this with sodium methoxide gives 3-methoxy-5-bromo-2-aminopyrazine (33.1.35).
Hydrogen reduction using a palladium on carbon catalyst replaces the bromine atom at C5 of
the product with a hydrogen atom, giving 3-methoxy-2-aminopyrazine (33.1.36).
This same 3-methoxy-2-aminopyrazine (33.1.36) is synthesized from 3-hydroxypyrazin-
2-carboxamide. Reacting this with phosphorous oxychloride replaces the hydroxyl group
with a chlorine atom while the carboxamide group simultaneously undergoes dehydration
to form 3-chloro-2-cyanopyrazine (33.1.37). Next, reacting this with sodium methoxide
gives 3-methoxy-2-cyanopyrazine (33.1.38). The cyano group in this compound is
hydrolyzed by a base in the presence of hydrogen peroxide to a carboxamide group, giving
3-methoxy-2-carboxamideopyrazine (33.1.39). The resulting product undergoes a Hofmann
rearrangement when reacted with sodium hypochlorite, giving the desired 3-methoxy-2
aminopyrazine (33.1.36). Reacting this with 4-acetylaminobenzenesulfonyl chloride and
subsequent hydrolysis of the acetyl group with a base to (33.1.40) gives sulfalene.
Sulfalen Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sulfalen manufacturers
- Product
- Sulfalen 152-47-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000
- Release date
- 2023-01-06
- Product
- Sulfamethoxypyrazine 152-47-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min CP
- Supply Ability
- 1000KGS
- Release date
- 2021-07-21
- Product
- Sulfalene 152-47-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-08