Epirizole
- Product Name
- Epirizole
- CAS No.
- 18694-40-1
- Chemical Name
- Epirizole
- Synonyms
- Dalex;da-398;mebron;epirizole;mepirizol;MEPIRIZOLE;Methopyrimazole;Epirizole USP/EP/BP;4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin;4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
- CBNumber
- CB4154565
- Molecular Formula
- C11H14N4O2
- Formula Weight
- 234.25
- MOL File
- 18694-40-1.mol
Epirizole Property
- Melting point:
- 90-92°
- Boiling point:
- 376.57°C (rough estimate)
- Density
- 1.1972 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 0.65±0.50(Predicted)
- form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 18694-40-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- UV9290000
- Toxicity
- LD50 orally in mice: 820 mg/kg (Ogura)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M9017
- Product name
- Mepirizole
- Purity
- analytical standard
- Packaging
- 10g
- Price
- $255.2
- Updated
- 2024/03/01
- Product number
- M225093
- Product name
- Mepirizole
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 454351
- Product name
- Mepirizole
- Packaging
- 10g
- Price
- $701
- Updated
- 2021/12/16
- Product number
- INB0000717
- Product name
- MEPIRIZOLE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1212.75
- Updated
- 2021/12/16
- Product number
- INB0000717
- Product name
- MEPIRIZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $328.65
- Updated
- 2021/12/16
Epirizole Chemical Properties,Usage,Production
Originator
Mebron,Daiichi Seiyaku,Japan,1970
Uses
Analgesic; anti-inflammatory.
Uses
Mepirizole induces precocious differentiation of insulin-producing ti-cells in larval zebrafish. Also, it increases the expression of MDR1 mRNA in Caco-2 cells; Non-acidic analgesic.
Definition
ChEBI: Epirizole is an aromatic ether.
Manufacturing Process
A mixture of 16.3 g of 4-methyl-6-methoxy-2-pyrimidinyl-hydrazine,13.7 g of
ethyl acetoacetate and 16.3 ml of methanol was refluxed 2 hours on a water
bath. After a mixture of 4.7 g of sodium hydroxide, 4.7 ml of water and 27 ml
of methanol was added dropwise thereto at about 50°C, the reaction mixture
was refluxed for 2 hours more, then methanol was distilled off and the residue
was dissolved in 130 ml of water. The solution was adjusted to pH 6 with
acetic acid. The precipitate was filtered, washed with water and dried to give
24 g (yield: 95.3%) of crystals, MP 97° to 98°C. Recrystallization from ligroin
gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-3-pyrazoline-5-one,
MP 102° to 103°C.
To a solution of 4.76 g of 1-( 4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-
3-pyrazoline 5-one in 200 ml of ether was added an ether solution containing
6 molar equivalents of diazomethane and the reaction mixture was allowed to
stand at room temperature for 20 hours. After distilling off the solvent, the
residue was dissolved in 160 ml of water, made alkaline (pH 10) with sodium
hydroxide solution and extracted three times with 140 ml of benzene. The
extract was washed with a small amount of water, dried over sodium sulfate
and evaporated to give a crystalline mass. Recrystallization from
isopropylether gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-5-
methoxypyrazole (3.96 g, 84%) as color less prisms, MP 90° to 92°C.
Therapeutic Function
Antiinflammatory, Analgesic, Antipyretic
Epirizole Preparation Products And Raw materials
Raw materials
Preparation Products
Epirizole Suppliers
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View Lastest Price from Epirizole manufacturers
- Product
- Epirizole 18694-40-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-15
- Product
- Epirizole 18694-40-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-30