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Epirizole

Product Name
Epirizole
CAS No.
18694-40-1
Chemical Name
Epirizole
Synonyms
Dalex;da-398;mebron;epirizole;mepirizol;MEPIRIZOLE;Methopyrimazole;Epirizole USP/EP/BP;4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin;4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
CBNumber
CB4154565
Molecular Formula
C11H14N4O2
Formula Weight
234.25
MOL File
18694-40-1.mol
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Epirizole Property

Melting point:
90-92°
Boiling point:
376.57°C (rough estimate)
Density 
1.1972 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
0.65±0.50(Predicted)
CAS DataBase Reference
18694-40-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UV9290000
Toxicity
LD50 orally in mice: 820 mg/kg (Ogura)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M9017
Product name
Mepirizole
Purity
analytical standard
Packaging
10g
Price
$255.2
Updated
2024/03/01
TRC
Product number
M225093
Product name
Mepirizole
Packaging
100mg
Price
$50
Updated
2021/12/16
Usbiological
Product number
454351
Product name
Mepirizole
Packaging
10g
Price
$701
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000717
Product name
MEPIRIZOLE
Purity
95.00%
Packaging
10G
Price
$1212.75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000717
Product name
MEPIRIZOLE
Purity
95.00%
Packaging
1G
Price
$328.65
Updated
2021/12/16
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Epirizole Chemical Properties,Usage,Production

Originator

Mebron,Daiichi Seiyaku,Japan,1970

Uses

Analgesic; anti-inflammatory.

Uses

Mepirizole induces precocious differentiation of insulin-producing ti-cells in larval zebrafish. Also, it increases the expression of MDR1 mRNA in Caco-2 cells; Non-acidic analgesic.

Definition

ChEBI: Epirizole is an aromatic ether.

Manufacturing Process

A mixture of 16.3 g of 4-methyl-6-methoxy-2-pyrimidinyl-hydrazine,13.7 g of ethyl acetoacetate and 16.3 ml of methanol was refluxed 2 hours on a water bath. After a mixture of 4.7 g of sodium hydroxide, 4.7 ml of water and 27 ml of methanol was added dropwise thereto at about 50°C, the reaction mixture was refluxed for 2 hours more, then methanol was distilled off and the residue was dissolved in 130 ml of water. The solution was adjusted to pH 6 with acetic acid. The precipitate was filtered, washed with water and dried to give 24 g (yield: 95.3%) of crystals, MP 97° to 98°C. Recrystallization from ligroin gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-3-pyrazoline-5-one, MP 102° to 103°C.
To a solution of 4.76 g of 1-( 4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl- 3-pyrazoline 5-one in 200 ml of ether was added an ether solution containing 6 molar equivalents of diazomethane and the reaction mixture was allowed to stand at room temperature for 20 hours. After distilling off the solvent, the residue was dissolved in 160 ml of water, made alkaline (pH 10) with sodium hydroxide solution and extracted three times with 140 ml of benzene. The extract was washed with a small amount of water, dried over sodium sulfate and evaporated to give a crystalline mass. Recrystallization from isopropylether gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-5- methoxypyrazole (3.96 g, 84%) as color less prisms, MP 90° to 92°C.

Therapeutic Function

Antiinflammatory, Analgesic, Antipyretic

Epirizole Preparation Products And Raw materials

Raw materials

Preparation Products

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Epirizole Suppliers

Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132020
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3974
Advantage
58
Shanghai BetterBioChem Co., Ltd.
Tel
+86-18017644823
Fax
- QQ:1910610264
Email
sales@betterbiochem.com
Country
China
ProdList
325
Advantage
58
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15820
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
29831
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
47465
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 15093356674;
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29826
Advantage
58
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View Lastest Price from Epirizole manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Epirizole 18694-40-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29
Dideu Industries Group Limited
Product
Epirizole 18694-40-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-15
Career Henan Chemical Co
Product
Epirizole 18694-40-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-30

18694-40-1, EpirizoleRelated Search:


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