1,3-Dimethyl-5-hydroxypyrazole
- Product Name
- 1,3-Dimethyl-5-hydroxypyrazole
- CAS No.
- 5203-77-0
- Chemical Name
- 1,3-Dimethyl-5-hydroxypyrazole
- Synonyms
- 2,5-DIMETHYL-3-PYRAZOLOL;1,3-DIMETHYL-1H-PYRAZOL-5-OL;2,5-Dimethyl-2H-pyrazol-3-ol;2,5-dimethyl-1H-pyrazol-3-one;1H-Pyrazol-5-ol, 1,3-dimethyl-;5-Hydroxy-1,3-dimethylpyrazole;1，3-dimethyl-1 H-pyrazol-5-one;1,3-DIMETHYL-1H-PYRAZOLE-5-ONE;1,3-Dimethyl-5-hydroxypyrazole;2,5-Dimethyl-1,2-dihydropyrazol-3-one
- CBNumber
- CB8147288
- Molecular Formula
- C5H8N2O
- Formula Weight
- 112.13
- MOL File
- 5203-77-0.mol
1,3-Dimethyl-5-hydroxypyrazole Property
- Melting point:
- 113-117°C
- Boiling point:
- 226°C
- Density
- 1.17
- Flash point:
- 90°C
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.19±0.28(Predicted)
- Appearance
- Off-white to pink Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D480188
- Product name
- 1,3-Dimethyl-1H-pyrazol-5-ol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 074659
- Product name
- 1,3-Dimethyl-1H-pyrazol-5-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FD131227
- Product name
- 1,3-Dimethyl-1H-pyrazol-5-ol
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- R031
- Product name
- 5-Hydroxy-1,3-dimethylpyrazole
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- FD131227
- Product name
- 1,3-Dimethyl-1H-pyrazol-5-ol
- Packaging
- 5G
- Price
- $80
- Updated
- 2021/12/16
1,3-Dimethyl-5-hydroxypyrazole Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Synthesis
141-97-9
60-34-4
5203-77-0
3.16 General procedure for the synthesis of 1-methyl-1H-pyrazol-5-ol (25a): a solution of methylhydrazine (2b) (0.57 mL, 10.9 mmol) in toluene (PhMe) (2 mL) was slowly added dropwise to a solution of ethyl acetoacetate (24) (1.39 mL, 10.9 mmol) in toluene (PhMe) (3 mL). The reaction mixture was stirred at room temperature for 5 min before the solvent was removed by vacuum evaporation. The product was purified by recrystallization (methanol/ethyl acetate mixed solvent) to give 1,3-dimethyl-5-hydroxypyrazole (0.90 g, 74% yield) as a light yellow solid with a melting point of 112-115°C (literature value: 112.5-113.5°C) (measured value: 113.0709). Molecular formula C5H9N2O [MH] Calculated value: 113.0709; FTIR (KBr) νmax/cm-1: 1549, 1269, 1185, 1034; 1H NMR (400 MHz, CDCl3) δ: 3.21 (3H, s, Me), 3.11 (2H, s, CH2), 2.02 (3H, s, 3-Me ); 13C NMR (100 MHz, CDCl3) δ: 172.2 (C), 155.5 (C), 41.4 (CH2), 31.0 (Me), 16.9 (Me); LRMS (APcI) m/z (Relative Intensity): 113 (MH+, 100).
References
[1] Tetrahedron, 2013, vol. 69, # 39, p. 8429 - 8438
[2] Letters in Drug Design and Discovery, 2016, vol. 13, # 8, p. 800 - 808
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 10, p. 2590 - 2594
1,3-Dimethyl-5-hydroxypyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-Dimethyl-5-hydroxypyrazole manufacturers
- Product
- 1,3-Dimethyl-5-hydroxypyrazole 5203-77-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24