3-ACETAMIDOPHENOL

ChemicalBook > CAS DataBase List > 3-ACETAMIDOPHENOL

3-ACETAMIDOPHENOL

Product Name: 3-ACETAMIDOPHENOL
CAS No.: 621-42-1
Chemical Name: 3-ACETAMIDOPHENOL
Synonyms: Nebs;bs479;BS 749;BS 479;Rystal;Metalid;Pyrapap;Pedituss;NSC 3990;metacetamol
CBNumber: CB0108898
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 621-42-1.mol

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3-ACETAMIDOPHENOL Property

Melting point:: 145-148 °C(lit.)
Boiling point:: 273.17°C (rough estimate)
Density: 1.249
refractive index: 1.5810 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol
pka: 9.50±0.10(Predicted)
form: Crystals, Crystalline Powder or Needles
color: Off-white to tan or light gray
PH: 6-7 (H2O)(saturated solution)
BRN: 907998
CAS DataBase Reference: 621-42-1(CAS DataBase Reference)
EPA Substance Registry System: 3'-Hydroxyacetanilide (621-42-1)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 2811
WGK Germany: 2
RTECS: AE4100000
F: 1-8
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29242995
Toxicity: LD50 intraperitoneal in mouse: 1025mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7205
Product name: 3-Acetamidophenol
Purity: 97%
Packaging: 25g
Price: $57.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 19374
Product name: 3-Acetamidophenol
Purity: analytical standard
Packaging: 100mg
Price: $95.9
Updated: 2022/05/15

TCI Chemical

Product number: H0188
Product name: 3'-Hydroxyacetanilide
Purity: >98.0%(T)
Packaging: 25g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: H0188
Product name: 3'-Hydroxyacetanilide
Purity: >98.0%(T)
Packaging: 500g
Price: $227
Updated: 2024/03/01

Alfa Aesar

Product number: A12764
Product name: 3-Acetamidophenol, 99%
Packaging: 25g
Price: $26.65
Updated: 2024/03/01

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3-ACETAMIDOPHENOL Chemical Properties,Usage,Production

Chemical Properties

off-white to tan or light grey crystals,

Uses

3-Acetamidophenol is the ortho-regioisomer of Acetaminophen (A161220), an over-the-counter analgesic and antipyretic agent (1,2).

Definition

ChEBI: A derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug.

General Description

Light gray solid.

Air & Water Reactions

Water insoluble.

Reactivity Profile

Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for 3-ACETAMIDOPHENOL are not available. 3-ACETAMIDOPHENOL is probably combustible.

Purification Methods

Recrystallise the phenol from water. The 3,5-dinitrobenzamide complex gives orange-yellow crystals from hot H2O and has m 212o. [Beilstein 13 H 415, 13 I 132, 13 II 213, 13 III 950, 13 IV 977.]

3-ACETAMIDOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

3-Ethoxyaniline

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3-ACETAMIDOPHENOL Suppliers

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View Lastest Price from 3-ACETAMIDOPHENOL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-ACETAMIDOPHENOL 621-42-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3"-Hydroxyacetanilide 621-42-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 3-ACETAMIDOPHENOL 621-42-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

621-42-1, 3-ACETAMIDOPHENOLRelated Search:

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N-(3-HYDROXYPHENYL)ACETAMIDE

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3-(Acetylamino)-1-hydroxybenzene

3-(Acetylamino)phenol

3’-hydroxy-acetanilid

3-Hydroxy-4-trimethylammoniobutanoate3'-hydroxyacetanilide

Acetamide, N-(3-hydroxyphenyl)-

Acetanilide, 3'-hydroxy-

BS 479

BS 749

bs479

m-(Acetylamino)phenol

metacetamol

Metalid

n-(3-hydroxyphenyl)-acetamid

N-Acetyl-m-Aminophenol

Nebs

Pedituss

Pyrapap

Rystal

3-ACETAMIDOPHENOL

3-ACETAMINOPHENOL

3'-HYDROXYACETANILIDE

3-HYDROXYACETANILIDE

M-ACETAMIDOPHENOL

M-ACETAMINOPHENOL

ACETAMIDOPHENOL-3

3-Acetamidophenol;N-Acetyl-m-aminophenol;m-Hydroxyacetanilide;3-Hydroxyacetanilide

META-HYDROXYACETANILIDE

N-ACETYL-META-AMINOPHENOL

3-ACETAMIDOPHENOL 99+%

m-Hydroxyacetanilide N-(3-Hydroxyphenyl)acetamide

N-(3-Hydroxyphenyl)acetamide, tech

3-AcetaMidophenol, 99+% 25GR

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3'-Hydroxyacetanilide , 98.0%(T)

3-Acetamidophenol 97%

Bosutinib Impurity 10

Neratinib-001

Prucalopride Impurity42

3'-Hydroxyacetanilide&gt

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N-(3-hydroxyphenyl)acetamide-d3

3'-Hydroxyacetanilide

621-42-1

Building Blocks

Phenols

Oxygen Compounds

Organic Building Blocks

Aromatic Phenols

Phenol&Thiophenol&Mercaptan

Anilines, Amides & Amines

Phenols