ChemicalBook > CAS DataBase List > 3-ACETAMIDOPHENOL

3-ACETAMIDOPHENOL

Product Name
3-ACETAMIDOPHENOL
CAS No.
621-42-1
Chemical Name
3-ACETAMIDOPHENOL
Synonyms
Nebs;bs479;BS 749;BS 479;Rystal;Metalid;Pyrapap;Pedituss;NSC 3990;metacetamol
CBNumber
CB0108898
Molecular Formula
C8H9NO2
Formula Weight
151.16
MOL File
621-42-1.mol
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3-ACETAMIDOPHENOL Property

Melting point:
145-148 °C(lit.)
Boiling point:
273.17°C (rough estimate)
Density 
1.249
refractive index 
1.5810 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol
pka
9.50±0.10(Predicted)
form 
Crystals, Crystalline Powder or Needles
color 
Off-white to tan or light gray
PH
6-7 (H2O)(saturated solution)
BRN 
907998
CAS DataBase Reference
621-42-1(CAS DataBase Reference)
EPA Substance Registry System
3'-Hydroxyacetanilide (621-42-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
2
RTECS 
AE4100000
1-8
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29242995
Toxicity
LD50 intraperitoneal in mouse: 1025mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7205
Product name
3-Acetamidophenol
Purity
97%
Packaging
25g
Price
$57.9
Updated
2023/06/20
Sigma-Aldrich
Product number
19374
Product name
3-Acetamidophenol
Purity
analytical standard
Packaging
100mg
Price
$95.9
Updated
2022/05/15
TCI Chemical
Product number
H0188
Product name
3'-Hydroxyacetanilide
Purity
>98.0%(T)
Packaging
25g
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
H0188
Product name
3'-Hydroxyacetanilide
Purity
>98.0%(T)
Packaging
500g
Price
$227
Updated
2024/03/01
Alfa Aesar
Product number
A12764
Product name
3-Acetamidophenol, 99%
Packaging
25g
Price
$26.65
Updated
2024/03/01
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3-ACETAMIDOPHENOL Chemical Properties,Usage,Production

Chemical Properties

off-white to tan or light grey crystals,

Uses

3-Acetamidophenol is the ortho-regioisomer of Acetaminophen (A161220), an over-the-counter analgesic and antipyretic agent (1,2).

Definition

ChEBI: A derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug.

General Description

Light gray solid.

Air & Water Reactions

Water insoluble.

Reactivity Profile

Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for 3-ACETAMIDOPHENOL are not available. 3-ACETAMIDOPHENOL is probably combustible.

Purification Methods

Recrystallise the phenol from water. The 3,5-dinitrobenzamide complex gives orange-yellow crystals from hot H2O and has m 212o. [Beilstein 13 H 415, 13 I 132, 13 II 213, 13 III 950, 13 IV 977.]

3-ACETAMIDOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-ACETAMIDOPHENOL Suppliers

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View Lastest Price from 3-ACETAMIDOPHENOL manufacturers

Hebei Duling International Trade Co. LTD
Product
3-ACETAMIDOPHENOL 621-42-1
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-01-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-ACETAMIDOPHENOL 621-42-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
3"-Hydroxyacetanilide 621-42-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

621-42-1, 3-ACETAMIDOPHENOLRelated Search:


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