ChemicalBook > CAS DataBase List > 2-Hydroxy-5-methyl-3-nitropyridine
2-Hydroxy-5-methyl-3-nitropyridine
- Product Name
- 2-Hydroxy-5-methyl-3-nitropyridine
- CAS No.
- 7464-14-4
- Chemical Name
- 2-Hydroxy-5-methyl-3-nitropyridine
- Synonyms
- 5-Methyl-3-nitro-2-pyridinol;2-HYDROXY-3-NITRO-5-PICOLINE;5-Methyl-3-nitropyridin-2-ol;6-Hydroxy-5-nitro-3-picoline;3-(NITRO)-5-METHYLPYRIDIN-2-OL;5-Methyl-3-nitro-2(1H)-pyridone;5-Methyl-3-nitropyridin-2(1H)-one;5-METHYL-3-NITRO-2(1H)-PYRIDINONE;2-HYDROXY-3-NITRO-5-METHYLPYRIDINE;2-HYDROXY-5-METHYL-3-NITROPYRIDINE
- CBNumber
- CB0109633
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 7464-14-4.mol
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2-Hydroxy-5-methyl-3-nitropyridine Property
- Melting point:
- 179 °C (dec.) (lit.)
- Boiling point:
- 353.3±35.0 °C(Predicted)
- Density
- 1.24 g/mL at 25 °C(lit.)
- Flash point:
- 179 °C
- storage temp.
- 2-8°C
- solubility
- soluble in Dimethylformamide
- form
- powder to crystal
- pka
- 8.78±0.10(Predicted)
- color
- White to Yellow
- CAS DataBase Reference
- 7464-14-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 551910
- Product name
- 2-Hydroxy-5-methyl-3-nitropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $50
- Updated
- 2023/01/07
TCI Chemical
- Product number
- H1483
- Product name
- 2-Hydroxy-5-methyl-3-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $91
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H1483
- Product name
- 2-Hydroxy-5-methyl-3-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $280
- Updated
- 2025/07/31
TRC
- Product number
- H973040
- Product name
- 2-Hydroxy-5-methyl-3-nitropyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
TRC
- Product number
- H973040
- Product name
- 2-Hydroxy-5-methyl-3-nitropyridine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
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2-Hydroxy-5-methyl-3-nitropyridine Chemical Properties,Usage,Production
Description
2-Hydroxy-5-methyl-3-nitropyridine (HMPN) is an organosynthetic compound that can be used as a feedstock for the synthesis of other compounds or as a biological inhibitor, such as in the preparation of 2-chloro-5-methyl-3-nitropyridine and transglutaminase 2 (tg2) inhibitors. It reacts with molybdenum and chloride. It is able to react with molybdenum and chloride, and it is able to increase the reaction yield and time. It is also used to explain its reactivity with xylene.
Chemical Properties
Powder or crystalline
Uses
2-Hydroxy-5-methyl-3-nitropyridine may be used in the preparation of 2-chloro-5-methyl-3-nitropyridine via chlorination, using thionyl chloride. It may also be used is preparing proteasome inhibitors containing 5-methylpyridin-2(1H)-one moiety.
Synthesis
1603-41-4
7464-14-4
Example 3: Synthesis of 2-(1-vinylimino)-5-carbamoyl-3-nitropyridine (Compound III) Reagents and conditions: (i) HNO3/H2SO4, followed by NaNO2. (ii) POCl3. (iii) Na2Cr2O7; (iv) SOCl2 (iv) SOCl2, followed by NH4OH/THF. (v) Aziridine. Steps for the synthesis of compound 14: 1. cool concentrated sulfuric acid (25 mL) in an ice bath, slowly add feedstock compound 13 (5 g, 0.0462 mol) and cool to 0 °C. 2. Slowly add 6 mL of a mixture of concentrated sulfuric acid (98%) and concentrated nitric acid (72%) in a volume ratio of 1:1 and keep the reaction temperature at 0-5 °C for 2 hours. 3. the reaction solution was poured into 100mL of ice water, 6g of sodium nitrite was added and stirring was continued in an ice bath for 4 hours. 4. The solid was precipitated, filtered and the filter cake was dried to give 4.4 g of compound 14 in 61.9% yield. 5. The melting point was determined to be 177-178 °C (water) (literature reports melting points of 178-180 °C) [J.O.C., 1944, 14, 328-332].
References
[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 8-9
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 9948 - 9956
2-Hydroxy-5-methyl-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Hydroxy-5-methyl-3-nitropyridine manufacturers
Dideu Industries Group Limited
- Product
- 2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-25
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