2-Hydroxy-5-nitropyridine
- Product Name
- 2-Hydroxy-5-nitropyridine
- CAS No.
- 5418-51-9
- Chemical Name
- 2-Hydroxy-5-nitropyridine
- Synonyms
- 5-Nitro-2-pyridol;5-Nitro-2-pyridone;5-NITRO-2-PYRIDINOL;5-Nirto-2-pyridinol;TIMTEC-BB SBB004167;5-Nitro-2-pyridinone;Hydroxy-5-nitropyrid;2-Pyridinol, 5-nitro-;5-(NITRO)PYRIDIN-2-OL;5-Nitro-2(1H)-pyridone
- CBNumber
- CB8401933
- Molecular Formula
- C5H4N2O3
- Formula Weight
- 140.1
- MOL File
- 5418-51-9.mol
2-Hydroxy-5-nitropyridine Property
- Melting point:
- 188-191 °C (lit.)
- Boiling point:
- 256.56°C (rough estimate)
- Density
- 1.5657 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Crystalline Powder
- pka
- 8.06±0.10(Predicted)
- color
- Light yellow to beige
- Water Solubility
- Soluble in hot water and alkali liquor, Insoluble in most of organic solvents.
- BRN
- 120352
- InChI
- InChI=1S/C5H4N2O3/c8-5-2-1-4(3-6-5)7(9)10/h1-3H,(H,6,8)
- InChIKey
- XKWSQIMYNVLGBO-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C([N+]([O-])=O)C=C1
- CAS DataBase Reference
- 5418-51-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Hydroxy-5-nitropyridine(5418-51-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H48808
- Product name
- 2-Hydroxy-5-nitropyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $82.4
- Updated
- 2025/07/31
- Product number
- H48808
- Product name
- 2-Hydroxy-5-nitropyridine
- Purity
- 97%
- Packaging
- 100g
- Price
- $233
- Updated
- 2025/07/31
- Product number
- H0673
- Product name
- 2-Hydroxy-5-nitropyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $145
- Updated
- 2025/07/31
- Product number
- H0673
- Product name
- 2-Hydroxy-5-nitropyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 250g
- Price
- $819
- Updated
- 2021/12/16
- Product number
- N900625
- Product name
- 5-Nitropyridin-2(1H)-one
- Packaging
- 5g
- Price
- $55
- Updated
- 2021/12/16
2-Hydroxy-5-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
light yellow to beige crystalline powder
Uses
A comparison of catalysts promotes imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst.
Synthesis
4214-76-0
5418-51-9
General procedure for the synthesis of 2-hydroxy-5-nitropyridine from 2-amino-5-nitropyridine: 2-amino-5-nitropyridine (13.9 g, 0.1 mol) was dissolved in 55.6 g of 15% dilute hydrochloric acid, and 44.85 g of 20% aqueous sodium nitrite (NaNO2) was added slowly dropwise. After the dropwise addition, the reaction was continued for 6 hours. The reaction temperature was maintained at 40°C for 40 minutes. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and a light yellow solid was precipitated after cooling. The solid was washed with ice water and dried to obtain 2-hydroxy-5-nitropyridine (12.61 g), which was analyzed by high performance liquid chromatography (HPLC) with a purity of 97.69% and a yield of 88.02%.
References
[1] Patent: CN105523995, 2016, A. Location in patent: Paragraph 0026; 0047; 0048
[2] Chemistry of Heterocyclic Compounds, 2002, vol. 38, # 7, p. 805 - 809
[3] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602
[4] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914, vol. 46, p. 1240
[5] Chem. Zentralbl., 1915, vol. 86, # I, p. 1066
2-Hydroxy-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Hydroxy-5-nitropyridine manufacturers
- Product
- 2-Hydroxy-5-nitropyridine 5418-51-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
- Product
- 2-Hydroxy-5-nitropyridine 5418-51-9
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-12-25
- Product
- 2-Hydroxy-5-nitropyridine 5418-51-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24