2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID

Product Name: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID
CAS No.: 5722-93-0
Chemical Name: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID
Synonyms: Acotiamide Impurity K;Acotinamide Impurity 4;Alcotimide intermediate 1;4,5-DiMethoxysalicylic acid;2-hydroxy-4,5-dimethoxybenzoic;2-Hydroxy-4,5-DimethoxyBenzoicAci;Acotiamide Hydrochloride impurity J;2-Hydroxy-4,5-dimethox benzoic acid;2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID;Benzoic acid, 2-hydroxy-4,5-dimethoxy-
CBNumber: CB81511758
Molecular Formula: C9H10O5
Formula Weight: 198.17
MOL File: 5722-93-0.mol

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2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID Property

Melting point:: 213-214℃ (decomposition)
Boiling point:: 361.5±42.0 °C(Predicted)
Density: 1.335±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.13±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H10O5/c1-13-7-3-5(9(11)12)6(10)4-8(7)14-2/h3-4,10H,1-2H3,(H,11,12)
InChIKey: RUBXSZYVSFYJQR-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(OC)=C(OC)C=C1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D461390
Product name: 4,5-DimethoxysalicylicAcid
Packaging: 250mg
Price: $160
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0388264
Product name: 2-HYDROXY-4,5-DIMETHOXYBENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $504.7
Updated: 2021/12/16

AK Scientific

Product number: 8404AB
Product name: 2-Hydroxy-4,5-dimethoxybenzoicacid
Packaging: 25g
Price: $636
Updated: 2021/12/16

Matrix Scientific

Product number: 095778
Product name: 2-Hydroxy-4,5-dimethoxybenzoic acid
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

Matrix Scientific

Product number: 095778
Product name: 2-Hydroxy-4,5-dimethoxybenzoic acid
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

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2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID Chemical Properties,Usage,Production

Uses

4,5-Dimethoxysalicylic Acid has been used as a reactant for the preparation of Salicylanilide derivatives as inhibitors of the protein tyrosine kinase epidermal growth factor receptor.

Synthesis

28373-21-9

5722-93-0

General procedure for synthesizing 2-hydroxy-4,5-dimethoxybenzoic acid from methyl 2-hydroxy-4,5-dimethoxybenzoate: sodium hydroxide (0.75 mol) and 100 mL of water were added to a reaction flask and stirred until clarified. Methyl 2-hydroxy-4,5-dimethoxybenzoate (0.25 mol) was suspended in the above alkaline solution according to the preparation method of Example 1 and stirred at room temperature for about 3.0 hours. The reaction progress was monitored by TLC, and after confirming the completion of the reaction, the reaction system was cooled to 10 °C, and the pH was adjusted slowly and dropwise to 4.0 by adding dilute hydrochloric acid.Subsequently, stirring, filtration, and drying were carried out, and 47.4 g of 2-hydroxy-4,5-dimethoxybenzoic acid was obtained, with a molar yield of 95.2% and a purity of 99.5% by HPLC.

References

[1] Patent: CN106316979, 2017, A. Location in patent: Paragraph 0044; 0045; 0046; 0047; 0048; 0049
[2] Journal of the American Chemical Society, 1942, vol. 64, p. 2983,2985

2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID Suppliers

Canada 1 China 169 India 3 United Kingdom 1 United States 8 Global 182

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View Lastest Price from 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID 5722-93-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-05

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID 5722-93-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

Hebei Yanxi Chemical Co., Ltd.

Product: 2-hydroxy-4,5-dimethoxybenzoic acid 5722-93-0
Price: US $150.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: ≥98%
Supply Ability: 5000kg/month
Release date: 2023-09-18

5722-93-0, 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACIDRelated Search:

2-Hydroxy-6-methyl-5-nitropyridine methyl (41R,12R,13aR)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile 1-(4-chloro-3-(trifluoromethyl)phenyl)urea 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE apovincamine Fludarabine EP impurity G 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Vortioxetine Impurity 4 (+)-(14β)-Dihydrovinpocetine 3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one 3-pentylisoindolin-1-one Acotiamide INT (4aS,7aS)-1-methyloctahydro-1H-pyrrolo[3,4-b]pyridine 3-ethyl-9-hydroxy-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one 3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone)

2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID

4,5-DiMethoxysalicylic acid

2-Hydroxy-4,5-Dimethoxy Benzoic Acid (for Acotiamide)

Acotiamide Impurity K

Acotiamide Hydrochloride impurity J

Acotinamide Impurity 4

2-hydroxy-4,5-dimethoxybenzoic

2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID（Acotinamide Impurity）

Benzoic acid, 2-hydroxy-4,5-dimethoxy-

2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID ISO 9001：2015 REACH

2-Hydroxy-4,5-DimethoxyBenzoicAci

Alcotimide intermediate 1

2-Hydroxy-4,5-dimethox benzoic acid

5722-93-0

5722-93-02

5300-65-8

5722-93-0