2-Hydroxy-6-methyl-5-nitropyridine

Product Name: 2-Hydroxy-6-methyl-5-nitropyridine
CAS No.: 28489-45-4
Chemical Name: 2-Hydroxy-6-methyl-5-nitropyridine
Synonyms: 2-Hydroxy-6-methyL;6-Methyl-5-nitro-2-pyridone;6-HYDROXY-3-NITRO-2-PICOLINE;6-METHYL-5-NITRO-2-PYRIDINOL;2-Hydorxy-5-Nitro-6-Picoline;2-HYDROXY-5-NITRO-6-PICOLINE;6-METHYL-5-NITROPYRIDIN-2-OL;and6-HYDROXY-3-NITRO-2-PICOLINE;6-Hydroxy-3-nitro-2-picoline,98%;6-Methyl-5-nitropyridin-2(1H)-one
CBNumber: CB0432362
Molecular Formula: C6H6N2O3
Formula Weight: 154.12
MOL File: 28489-45-4.mol

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2-Hydroxy-6-methyl-5-nitropyridine Property

Melting point:: 230-232 °C
Boiling point:: 277.46°C (rough estimate)
Density: 1.4564 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Dimethylformamide
pka: 8.16±0.10(Predicted)
form: Crystalline Powder
color: Light brown to brown
InChI: InChI=1S/C6H6N2O3/c1-4-5(8(10)11)2-3-6(9)7-4/h2-3H,1H3,(H,7,9)
InChIKey: AJDDHNXZBGZBJN-UHFFFAOYSA-N
SMILES: C1(=O)NC(C)=C([N+]([O-])=O)C=C1
CAS DataBase Reference: 28489-45-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 37/39-26
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1160
Product name: 6-Hydroxy-2-methyl-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: H1160
Product name: 6-Hydroxy-2-methyl-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: H947608
Product name: 2-Hydroxy-6-methyl-5-nitropyridine
Packaging: 1g
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 076676
Product name: 6-Methyl-5-nitropyridin-2-ol
Packaging: 1g
Price: $48
Updated: 2021/12/16

AK Scientific

Product number: J53599
Product name: 2-Hydroxy-5-nitro-6-picoline
Packaging: 1g
Price: $15
Updated: 2021/12/16

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2-Hydroxy-6-methyl-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow cryst

Uses

2-Hydroxy-6-methyl-5-nitropyridine is a versatile building block that can be used to create a range of compounds, such as 3-Amino-2-methylpyridine, 6-Chloro-2-methyl-3-nitropyridine, etc.

Synthesis

22280-62-2

28489-45-4

General procedure for the synthesis of 2-hydroxy-6-methyl-5-nitropyridine from 2-amino-5-nitro-6-methylpyridine: (b) 6-amino-3-nitro-2-methylpyridine (20 g, 0.131 mol) was suspended in a mixture of concentrated hydrochloric acid, H2SO4 (23.7 ml) and water (335 ml). H2SO4 (20 ml) was added slowly under cooling in an ice bath, at which point the amine was not completely dissolved. The suspension was poured into ice (100 g), followed by the addition of NaNO2 (13.53 g, 0.196 mol) solution in water (40 ml) drop by drop. Gas escaped during the reaction. The brown suspension was stirred at 10 °C for 1 h. Subsequently, it was filtered and the precipitate was washed with cold water. The resulting brown product was dried in a freeze dryer to give a final 15.78 g of 6-hydroxy-3-nitro-2-methylpyridine in 78% yield.

References

[1] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 33
[2] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[3] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0020
[4] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830
[5] Yakugaku Zasshi, 1952, vol. 72, p. 434

2-Hydroxy-6-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Potassium hydroxide 2-Amino-6-methylpyridine Sodium nitrite Nitric acid Sulfuric acid

Preparation Products

3-AMINO-2-CHLORO-6-PICOLINE

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2-Hydroxy-6-methyl-5-nitropyridine Suppliers

Americas 1 Belgium 1 China 193 Europe 3 France 1 Germany 5 India 27 Japan 1 Switzerland 1 United Kingdom 6 United States 34 Global 273

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Energy Chemical

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View Lastest Price from 2-Hydroxy-6-methyl-5-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Hydroxy-6-methyl-5-nitropyridine 28489-45-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Fengda Chemical Co., Ltd

Product: 2-Hydroxy-6-methyl-5-nitropyridine 28489-45-4
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Hydroxy-6-methyl-5-nitropyridine 28489-45-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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6-Hydroxy-3-nitro-2-picoline 6-Methyl-5-nitro-2-pyridinol

6-Methyl-5-nitropyridin-2(1H)-one

6-Methyl-5-nitropyridin-2-ol, 6-Methyl-5-nitropyridin-2(1H)-one, 6-Hydroxy-3-nitro-2-picoline

2(1H)-Pyridinone, 6-methyl-5-nitro-

6-methyl-5-nitro-1H-pyridin-2-one

6-methyl-5-nitro-1,2-dihydropyridin-2-one

6-Hydroxy-2-methyl-3-nitropyridine&gt

2-Hydroxy-6-methyL

6-Methyl-5-nitro-2(1H)-pyridinone

2-Hydroxy-6-methyl-5-nitropyridine ISO 9001：2015 REACH

28489-45-4

2848-45-4

28489-45-5

Heterocycle-Pyridine series

Pyridine

Pyridines