ChemicalBook > CAS DataBase List > 2-Hydroxy-6-methyl-5-nitropyridine
2-Hydroxy-6-methyl-5-nitropyridine
- Product Name
- 2-Hydroxy-6-methyl-5-nitropyridine
- CAS No.
- 28489-45-4
- Chemical Name
- 2-Hydroxy-6-methyl-5-nitropyridine
- Synonyms
- 2-Hydroxy-6-methyL;6-Methyl-5-nitro-2-pyridone;6-HYDROXY-3-NITRO-2-PICOLINE;6-METHYL-5-NITRO-2-PYRIDINOL;2-Hydorxy-5-Nitro-6-Picoline;2-HYDROXY-5-NITRO-6-PICOLINE;6-METHYL-5-NITROPYRIDIN-2-OL;and6-HYDROXY-3-NITRO-2-PICOLINE;6-Hydroxy-3-nitro-2-picoline,98%;6-Methyl-5-nitropyridin-2(1H)-one
- CBNumber
- CB0432362
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 28489-45-4.mol
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2-Hydroxy-6-methyl-5-nitropyridine Property
- Melting point:
- 230-232 °C
- Boiling point:
- 277.46°C (rough estimate)
- Density
- 1.4564 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Dimethylformamide
- pka
- 8.16±0.10(Predicted)
- form
- Crystalline Powder
- color
- Light brown to brown
- InChI
- InChI=1S/C6H6N2O3/c1-4-5(8(10)11)2-3-6(9)7-4/h2-3H,1H3,(H,7,9)
- InChIKey
- AJDDHNXZBGZBJN-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(C)=C([N+]([O-])=O)C=C1
- CAS DataBase Reference
- 28489-45-4(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- H1160
- Product name
- 6-Hydroxy-2-methyl-3-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H1160
- Product name
- 6-Hydroxy-2-methyl-3-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
TRC
- Product number
- H947608
- Product name
- 2-Hydroxy-6-methyl-5-nitropyridine
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 076676
- Product name
- 6-Methyl-5-nitropyridin-2-ol
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
AK Scientific
- Product number
- J53599
- Product name
- 2-Hydroxy-5-nitro-6-picoline
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
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2-Hydroxy-6-methyl-5-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow cryst
Uses
2-Hydroxy-6-methyl-5-nitropyridine is a versatile building block that can be used to create a range of compounds, such as 3-Amino-2-methylpyridine, 6-Chloro-2-methyl-3-nitropyridine, etc.
Synthesis
22280-62-2
28489-45-4
General procedure for the synthesis of 2-hydroxy-6-methyl-5-nitropyridine from 2-amino-5-nitro-6-methylpyridine: (b) 6-amino-3-nitro-2-methylpyridine (20 g, 0.131 mol) was suspended in a mixture of concentrated hydrochloric acid, H2SO4 (23.7 ml) and water (335 ml). H2SO4 (20 ml) was added slowly under cooling in an ice bath, at which point the amine was not completely dissolved. The suspension was poured into ice (100 g), followed by the addition of NaNO2 (13.53 g, 0.196 mol) solution in water (40 ml) drop by drop. Gas escaped during the reaction. The brown suspension was stirred at 10 °C for 1 h. Subsequently, it was filtered and the precipitate was washed with cold water. The resulting brown product was dried in a freeze dryer to give a final 15.78 g of 6-hydroxy-3-nitro-2-methylpyridine in 78% yield.
References
[1] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 33
[2] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[3] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0020
[4] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830
[5] Yakugaku Zasshi, 1952, vol. 72, p. 434
2-Hydroxy-6-methyl-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Hydroxy-6-methyl-5-nitropyridine manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 2-Hydroxy-6-methyl-5-nitropyridine 28489-45-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
Henan Fengda Chemical Co., Ltd
- Product
- 2-Hydroxy-6-methyl-5-nitropyridine 28489-45-4
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Hydroxy-6-methyl-5-nitropyridine 28489-45-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
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