4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

Product Name: 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
CAS No.: 320-51-4
Chemical Name: 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
Synonyms: 4-CHLORO-3-(TRIFLUOROMETHYL)ANILINE;5-AMINO-2-CHLOROBENZOTRIFLUORIDE;5-AMINO-2-CHLOROTRIFLUOROTOLUENE;4-CHLORO-3-TRIFLUOROMETHYL-PHENYLAMINE;4-Chloro-3-(trifluoromethyl)-benzenamine;AI-ZA04;NSC 61405;oro-3-(trifL;TIMTEC-BB SBB003592;Regofenib impurity 5
CBNumber: CB3488214
Molecular Formula: C7H5ClF3N
Formula Weight: 195.57
MOL File: 320-51-4.mol

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4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Property

Melting point:: 35-37 °C(lit.)
Boiling point:: 85 °C (3 mmHg)
Density: 1.4070 (estimate)
vapor pressure: 13Pa at 25℃
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Crystalline Powder or Low Melting Solid
pka: 2.74±0.10(Predicted)
color: White to pinkish or slightly orange
FreezingPoint: 34.0 to 37.0 ℃
BRN: 641588
InChIKey: ASPDJZINBYYZRU-UHFFFAOYSA-N
LogP: 2.68 at 25℃
CAS DataBase Reference: 320-51-4(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 4-chloro-3-(trifluoromethyl)-(320-51-4)
EPA Substance Registry System: Benzenamine, 4-chloro-3-(trifluoromethyl)- (320-51-4)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 36/37/38-23/24/25-22-36/38-20/21/22
Safety Statements: 22-24/25-45-36-26-36/37
RIDADR: UN2811
WGK Germany: 2
Hazard Note: Irritant
TSCA: T
HazardClass: 6.1
PackingGroup: III
HS Code: 29214300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002227
Product name: Regorafenib impurity FP-B
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: A45653
Product name: 4-Chloro-3-(trifluoromethyl)aniline
Purity: 99%
Packaging: 25g
Price: $34.67
Updated: 2025/07/31

TCI Chemical

Product number: C0922
Product name: 5-Amino-2-chlorobenzotrifluoride
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: C0922
Product name: 5-Amino-2-chlorobenzotrifluoride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $64
Updated: 2025/07/31

Strem Chemicals

Product number: 09-1070
Product name: 5-Amino-2-chlorobenzotrifluoride, min. 97%
Packaging: 5g
Price: $29
Updated: 2024/03/01

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4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Chemical Properties,Usage,Production

Chemical Properties

white to pinkish crystalline powder

Uses

5-Amino-2-chlorobenzotrifluoride is a compound useful in organic synthesis. It also performs a radioprotective activity against ionizing radiations.

Definition

ChEBI: A monochlorobenzene that is the 3-trifluoromethyl derivative of 4-chloroaniline.

Synthesis

777-37-7

320-51-4

General procedure for the synthesis of 2-chloro-5-aminobenzotrifluoride from 2-chloro-5-nitrobenzotrifluoride: In 1.0 mL of 2 wt% TPGS/H2O solution, 1-chloro-4-nitro-2-(trifluoromethyl)benzene (113 mg, 0.50 mmol), Fe nanoparticles (6 mg) and NaBH4 (28.5 mg, 0.75 mmol) were added. The reaction was carried out at room temperature for 2 hours. Upon completion of the reaction, 91.7 mg (94% yield) of 4-chloro-3-(trifluoromethyl)aniline was obtained as a colorless oil (hexane/ethyl acetate = 80/20). The spectral data of the product were in agreement with those reported in the literature.GC-MS analysis showed m/z: 195 [M]+.

References

[1] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 31, p. 8979 - 8983
[3] Angew. Chem., 2016, vol. 128, # 31, p. 9125 - 9129,5
[4] Patent: WO2017/106426, 2017, A1. Location in patent: Paragraph 0084; 0088
[5] Patent: CN108191670, 2018, A. Location in patent: Paragraph 0047; 0050; 0053; 0056; 0057-0059; 0062-0068

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Preparation Products And Raw materials

Raw materials

Preparation Products

4-CHLORO-3-(TRIFLUOROMETHYL)BENZYL BROMIDE

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4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Suppliers

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Fuxin Xin Kaida Fluorine Chemistry Co., Ltd.

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View Lastest Price from 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-Chloro-3-Trifluoromethyl aniline 320-51-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 320-51-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Amino-2-chlorobenzotrifluoride 320-51-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-13

320-51-4, 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidineRelated Search:

ETHYL 4-CHLORO-3-TRIFLUOROMETHYLCARBANILATE Sorafenib IMpurity Sorafenib related coMpound 8 Sorafenib related compound 10 Sorafenib Related Compound 21 Sorafenib Impurity 1 Sorafenib related coMpound 5 Sorafenib Related Compound 13 Sorafenib related coMpound 1 4-(4-Aminophenoxy)-N-methylpicolinamide Sorafenib IMpurity C Sorafenib Impurity 6 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Sorafenib related coMpound 6 Sorafenib Related Compound 22 N-Methyl-4-chloropyridine-2-carboxamide Sorafenib related compound 11 Sorafenib related coMpound 7

5-AMINO-2-CHLOROTRIFLUOROTOLUENE

5-AMINO-2-CHLOROBENZOTRIFLUORIDE

4-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE

4-CHLORO-3-TRIFLUOROMETHYL-PHENYLAMINE

4-CHLORO-3-(TRIFLUOROMETHYL)ANILINE

4-Chloro-3-(trifluoromethyl)-benzenamine

4-AMINO-1-CHLORO-2-(TRIFLUOROMETHYL)BENZENE

2-CHLORO-5-AMINEBENZOTRIFLUORIDE

2-CHLORO-5-AMINOBENZOTRIFLUORIDE

LABOTEST-BB LT00077053

TIMTEC-BB SBB003592

3-(Trifluoromethyl)-4-chloroaniline

4-chloro-3-(trifluoromethyl)-benzenamin

6-Chloro-3-aminobenzotrifluoride

Aniline, 4-chloro-3-(trifluoromethyl)-

Benzenamine,4-chloro-3-(trifluoromethyl)-

Benzenamine,4-chloro-3-trifluoromethyl-

m-Toluidine, 4-chloro-alpha,alpha,alpha-trifluoro-

5-Amino-2-chlorobenzotrifluoride,97%

5-Amino-2-chlorobenzotrifluoride,min.97%

5-Amino-2-chlorobenzotrifluoride 97%

4-chloro-3-(Trilfuoromethyl)aniline

4-Chloro-5--Amino benzotrifluoride

5-AMINO-2-CHLOROBENZOTRIFLUORIDE (4-CHLORO-3-TRIFLUOROMETHYLANILINE)

2-CHLORO-5-AMINOBENZOTRIFLUORIDE 98%

4-Chloro-α,α,α-trifluoro-m-toluidine, 5-Amino-2-chlorobenzotrifluoride

4-chloro-3-(trifluoromethyl)anilin

5-Amino-2-chlorobenzotrifluoride, min. 97%

5-Amino-2-chlorobenzotrifluoride,99%

4-AMINO-1-CHLORO-2-(TRIF

oro-3-(trifL

Regofenib impurity 5

5-Amino-2-chlorobenzotrifluoride（2-Chloro-5-aminobenzotrifluoride）

5-AMino-2-chlorobenzotrifluoride, 99% 25GR

5-AMino-2-chlorobenzotrifluoride, 99% 5GR

4-Chloro-alpha,alpha

3-AMino-6-chlorobenzotrifluoride

NSC 61405

4-Chlorine-3-(trifluoroMethyl)aniline

4-Amino-1-chloro-2-(trifluoromethyl)benzene 4-Chloro-3-trifluoromethylaniline

4-Chloro-3-(trifluoromethyl)aniline, 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

2 - chloro - 5 - aMino toluene three fluorine

Chlorine - 4-3-3 Methylaniline

Sorafenib Impurity 5

5-Amino-2-chlorobenzotrifluoride for synthesis

Sorafenib Impurity E

5-Amino-2-chlorobenzotrifluoride &gt

4-Chlor-α,α,α-trifluor-m-toluidin

4-Chloro-3-(trifluoromethyl)aniline? (Regorafenib Impurity)

Sorafenib Impurity 5(Regorafenib Impurity 5)

AI-ZA04

5-Amino-2-chlorobenzotrifluride

4-chloro-α,α,α-trifluoro-m-toluidine

2-chloro-5-aminotrifluorotoluene

320-51-4

320-98-4

NH2ClC6H3CF3

ClC6H3CF3NH2