Sorafenib IMpurity
- Product Name
- Sorafenib IMpurity
- CAS No.
- 1256817-30-7
- Chemical Name
- Sorafenib IMpurity
- Synonyms
- Sorafenib Impurity;Sorafenib Impurity 24;Sorafenib Related Compound 16;Methyl 4-(Methylamino)picolinate;methyl 4-(methylamino)pyridine-2-carboxylate;Sorafenib impurity 7/Methyl 4-(Methylamino)picolinate;methyl 4-(methylamino)picolinate? (Sorafenib Impurity）;2-Pyridinecarboxylic acid, 4-(methylamino)-, methyl ester;4-(4-(3-(2-chloro-3-(trifluoroMethyl)phenyl)ureido)phenoxy)-N-MethylpicolinaMide
- CBNumber
- CB02668503
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 1256817-30-7.mol
Sorafenib IMpurity Property
- Boiling point:
- 326.9±27.0 °C(Predicted)
- Density
- 1.186±0.06 g/cm3(Predicted)
- pka
- 4.84±0.10(Predicted)
- CAS DataBase Reference
- 1256817-30-7
N-Bromosuccinimide Price
- Product number
- M321155
- Product name
- Methyl4-(Methylamino)picolinate
- Packaging
- 10g
- Price
- $1680
- Updated
- 2021/12/16
Sorafenib IMpurity Chemical Properties,Usage,Production
Uses
Methyl 4-(Methylamino)picolinate is a pyridinyl building block and a useful synthetic intermediate.
Synthesis
Add 0.8 g (0.004 mol) of 2-chloro-3-trifluoromethyl aniline and 0.7 g (0.004 mol) of N,N-carbonyl diimidazole to 10 mL of dichloromethane, stirring at room temperature for 4 h. Add 0.6 g (0.002 mol) of Compound 2, stirring for 6 h. Distil under reduced pressure and purify by column chromatographic separation (silica gel 200-300 mesh; eluent: V (hexane ):V(ethyl acetate)=5:1), concentrated to dryness to obtain 0.5g product 4-{4-[3-(2-chloro-3-trifluoromethyl-phenyl)-acyl urea]-phenoxy}-pyridine-2-carboxylic acid methyl amine, yield 43.5%, m.p. 188??190??C, purity 96.7%. (HPLC method: octadecylsilane-bonded silica gel as filler, mobile phase A: phosphate buffer, mobile phase B: V (acetonitrile):V (ethanol) = 70:30, flow rate 0.8 mL/min, detection wavelength 240 nm, RT = 29.61 min).
Sorafenib IMpurity Preparation Products And Raw materials
Raw materials
Preparation Products
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