2-Chloro-5-nitrobenzotrifluoride

Product Name: 2-Chloro-5-nitrobenzotrifluoride
CAS No.: 777-37-7
Chemical Name: 2-Chloro-5-nitrobenzotrifluoride
Synonyms: 1-CHLORO-4-NITRO-2-(TRIFLUOROMETHYL)BENZENE;TIMTEC-BB SBB007665;2-chloro-5-nitrobenzotrifuoride;2-chloro-5-nitrotrifluorotoluol;2-Chloro-5-nitrobenzotriluoride;2-CHLORO-5-NITROBENZOTRIFLUORIDE;5-NITRO-2-CHLOROBENZOTRIFLUORIDE;2-Chloro-5-nitrobenzotrifluoride98%;2-Chloro-5-nitrobenzotrifluoride,96%;2-Chloro-5-nitrobenzotrifluoride 98%
CBNumber: CB1117093
Molecular Formula: C7H3ClF3NO2
Formula Weight: 225.55
MOL File: 777-37-7.mol

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2-Chloro-5-nitrobenzotrifluoride Property

Melting point:: 22°C
Boiling point:: 108 °C/10 mmHg (lit.)
Density: 1.527 g/mL at 25 °C (lit.)
refractive index: n20/D 1.508(lit.)
Flash point:: 210 °F
storage temp.: Sealed in dry,Room Temperature
form: powder to lump to clear liquid
color: White or Colorless to Yellow
Specific Gravity: 1.527
FreezingPoint: 20.0 to 23.0 ℃
BRN: 2216169
Exposure limits: ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3
InChIKey: HQROXDLWVGFPDE-UHFFFAOYSA-N
CAS DataBase Reference: 777-37-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-chloro-4-nitro-2-(trifluoromethyl)-(777-37-7)
EPA Substance Registry System: 2-Chloro-5-nitrobenzotrifluoride (777-37-7)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36/37/39-36
RIDADR: 2810
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C60406
Product name: 2-Chloro-5-nitrobenzotrifluoride
Purity: 97%
Packaging: 25g
Price: $25.1
Updated: 2025/07/31

TCI Chemical

Product number: C0923
Product name: 2-Chloro-5-nitrobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 25g
Price: $26
Updated: 2025/07/31

TRC

Product number: C597078
Product name: 2-Chloro-5-nitrobenzotrifluoride
Packaging: 5g
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 269380
Product name: 2-Chloro-5-nitrobenzotrifluoride
Packaging: 100g
Price: $360
Updated: 2021/12/16

AK Scientific

Product number: J93539
Product name: 2-Chloro-5-nitrobenzotrifluoride
Packaging: 5g
Price: $10
Updated: 2021/12/16

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2-Chloro-5-nitrobenzotrifluoride Chemical Properties,Usage,Production

Chemical Properties

Clear colourless to light yellow liquid

Uses

2-Chloro-5-nitrobenzotrifluoride is a polysubstituted organic fluorotoluene analogue. Its molecular structure has a reactive group chlorine atom at the 2-position and a nitro group at the 5-position. Therefore, the substance has high chemical reactivity and is widely used in the field of organic synthesis. It can be used to prepare asymmetric and symmetric diamine monomers containing trifluoromethyl groups, which in turn can be used to further prepare soluble polyimide, a multifunctional molecular material^[1].

Synthesis

88-16-4

777-37-7

1) 400 g of o-chlorobenzotrifluoride (Feedstock I) was added to Preheating Module 2. Concentrated sulfuric acid (Feedstock II) and concentrated nitric acid (Feedstock III) were added to Preheating Module 1 for mixing and preheating, respectively. Subsequently, feedstocks I, II and III were introduced into the reaction module set for nitrification reaction. The flow rate of feedstock I was controlled to be 15 mL/min, the flow rate of feedstock II to be 18 mL/min, and the flow rate of feedstock III to be 11.5 mL/min by adjusting the flow pump. the reaction temperature was maintained at 60°C. The reaction temperature was maintained at 60°C. The flow rate of feedstock I was controlled to be 15 mL/min. The molar ratio of o-chlorobenzotrifluoride to nitric acid was 1:1.2, and the mass ratio of concentrated nitric acid to concentrated sulfuric acid was 1:4.0, and the reaction residence time was 55 seconds. The temperature of the cooling module was set to 25°C. The reaction solution at the outlet of the cooling module was collected for liquid-liquid separation. The product was combined with the organic phase by adding 270 mL of dichloromethane to the acid phase. It was washed with saturated sodium bicarbonate solution to neutrality and subsequently dried with anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, 480.36 g of 2-chloro-5-nitrobenzotrifluoride was obtained as a yellow oil. The yield was 96.13% and the purity was 99.29%.

References

[1] SUN DAL KIM . Soluble polyimides with trifluoromethyl pendent groups[J]. Polymer, 2013. DOI:10.1016/j.polymer.2013.08.057.

2-Chloro-5-nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-nitrobenzotrifluoride Suppliers

Americas 1 Belgium 1 Canada 1 China 279 Europe 4 France 1 Germany 4 India 7 Italy 1 Japan 4 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 38 Global 357

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View Lastest Price from 2-Chloro-5-nitrobenzotrifluoride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-5-nitrobenzotrifluoride 777-37-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-5-nitrobenzotrifluoride 777-37-7
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Chloro-5-nitrobenzotrifluoride 777-37-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-20

777-37-7, 2-Chloro-5-nitrobenzotrifluorideRelated Search:

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2-Chloro-5-nitrobenzotriluoride

5-NITRO-2-CHLOROBENZOTRIFLUORIDE

TIMTEC-BB SBB007665

1-chloro-4-nitro-2-(trifluoromethyl)-benzen

2-(Trifluoromethyl)-4-nitrochlorobenzene

2-chloro-1-trifluoromethyl-5-nitro-benzene

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3-(Trifluoromethyl)-4-chloronitrobenzene

4-Chloro-3-(trifluoromethyl)nitrobenzene

Benzene,1-chloro-4-nitro-2-(trifluoromethyl)-

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α,α,α-trifluoro-2-chloro-5-nitrotoluene

4-Nitro-2-(trifluoromethyl)chlorobenzene

2-Chloro-5-nitrobenzotrifluoride &gt

2-Chlor-α,α,α-trifluor-5-nitrotoluol

777-37-7

777-37-3

C7H3NO2ClF3

Building Blocks

Nitro Compounds

Organic Building Blocks

Nitrogen Compounds

Trifluoromethylbenzene serise

API Intermediate

alkyl chloride| nitro-compound