(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile

Product Name: (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile
CAS No.: 1640971-60-3
Chemical Name: (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile
Synonyms: tofacitinib iMpurity;Tofacitinib Impurity 21;PF-05579970;Tofatib reference;ofacitinib iMpurity;(3R,4R)-Tofacitinib;Tofaimpurity iMpurity;Tofatinib Impurity 21;Tofacitinib Impurity 9;Tofacitinib ImpurityBA
CBNumber: CB72663305
Molecular Formula: C14H20N6O
Formula Weight: 288.35
MOL File: 1640971-60-3.mol

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(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile Property

Melting point:: 238 - 240°C
Boiling point:: 551.0±50.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 6.06±0.60(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T528045
Product name: TofacitinibCitrateImpurity
Packaging: 25mg
Price: $130
Updated: 2021/12/16

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(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile Chemical Properties,Usage,Production

Uses

Tofacitinib Citrate Impurity is derived from (3R,4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine (D464895), which is a reagent used in the preparation of Janus tyrosine kinase inhibitors for the treatment of autoimmune diseases.

(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile Suppliers

China 80 India 3 United States 4 Global 87

BOC Sciences

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View Lastest Price from (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile manufacturers

Moxin Chemicals

Product: Tofacitinib Impurity TBA 1640971-60-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95
Supply Ability: 100000
Release date: 2025-02-12

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Tofacitinib Impurity TBA 1640971-60-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-25

Career Henan Chemical Co

Product: (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile 1640971-60-3
Price: US $6.60/KG
Min. Order: 500g
Purity: 98%
Supply Ability: 1KG, 50KG, 100KG
Release date: 2019-12-25

1640971-60-3, (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-PiperidinepropanenitrileRelated Search:

Etoricoxib IMpurity 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone BENZOOXAZOL-2-YLAMINE (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester 7-(4-Hydroxybutoxy-4,4-d2)-2(1H)-quinolinone Sorafenib IMpurity Rocuronium Bromide Impurity Piperacillin Impurity Sildenafil Aldehyde IMpurity Sulbactam Impurity Tenofovirdisoproxil Impurity LUMACAFTOR IMPURITY Dapagliflozin iMpurity N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine (3S,4S)-1-benzyl-N,4-diMethylpiperidin-3-aMine N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile Tofacitinib related coMpound 2

ofacitinib iMpurity

Tofacitinib Citrate Impurity

tofacitinib iMpurity

Tofacitinib Impurity 11

3-((3R,4R)-3-((6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl) (methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate-one

Tofacitinib Impurity TBA

Tofacitinib Impurity 5 DiHCl

N2,N4-bis((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N2,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Tofacitinib Impurity 14

Tofacitinib Impurity 15

Tofacitinib Impurity 18

Tofacitinib Impurity 21

Tofacitinib Impurity 9

PF-05579970

3-((3R,4R)-4-methyl-3-(methyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

Tofaimpurity iMpurity

Tofacitinib Related Compound 11

butyl (E)-3-amino-2-cyano-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enoate

Tofacitinib Impurity TAB

1-Piperidinepropanenitrile, 3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-, (3R,4R)-

Tofatib reference

Tofacitinib Impurities1006

Tofacitinib Impurities1007

Tofacitinib Impurities1008

Tofacitinib Impurities1009

3-[3-((6-Amino-pyrimidin-4-yl)-methyl-amino)-4-methyl-piperidin-1-yl]-3-oxo-propionitrile

Tofatinib Impurity 21

(3R,4R)-3-[(6-Amino-4-pyrimidinyl)methylamino]-4-methyl-Beta-oxo-1-piperidinepropanenitrile

(3RS,4SR)-1-benzyl-N,4-dimethylpiperidin-3-amine

Tofacitinib ImpurityBA

3-((3R,4R)-3-((6-Aminopyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile (Tofacitinib Impurity）

3-((3R,4R)-3-((2-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

3-((3R,4R)-3-((4-aminopyrimidin-2-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

(3R,4R)-Tofacitinib

1640971-60-3

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