ChemicalBook > CAS DataBase List > 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

Product Name
4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
CAS No.
320-51-4
Chemical Name
4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
Synonyms
4-CHLORO-3-(TRIFLUOROMETHYL)ANILINE;5-AMINO-2-CHLOROBENZOTRIFLUORIDE;5-AMINO-2-CHLOROTRIFLUOROTOLUENE;4-CHLORO-3-TRIFLUOROMETHYL-PHENYLAMINE;4-Chloro-3-(trifluoromethyl)-benzenamine;AI-ZA04;NSC 61405;oro-3-(trifL;TIMTEC-BB SBB003592;Regofenib impurity 5
CBNumber
CB3488214
Molecular Formula
C7H5ClF3N
Formula Weight
195.57
MOL File
320-51-4.mol
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4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Property

Melting point:
35-37 °C(lit.)
Boiling point:
85 °C (3 mmHg)
Density 
1.4070 (estimate)
vapor pressure 
13Pa at 25℃
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Crystalline Powder or Low Melting Solid
pka
2.74±0.10(Predicted)
color 
White to pinkish or slightly orange
FreezingPoint 
34.0 to 37.0 ℃
BRN 
641588
InChIKey
ASPDJZINBYYZRU-UHFFFAOYSA-N
LogP
2.68 at 25℃
CAS DataBase Reference
320-51-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 4-chloro-3-(trifluoromethyl)-(320-51-4)
EPA Substance Registry System
Benzenamine, 4-chloro-3-(trifluoromethyl)- (320-51-4)
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Safety

Hazard Codes 
Xi,T,Xn
Risk Statements 
36/37/38-23/24/25-22-36/38-20/21/22
Safety Statements 
22-24/25-45-36-26-36/37
RIDADR 
UN2811
WGK Germany 
2
Hazard Note 
Irritant
TSCA 
T
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002227
Product name
Regorafenib impurity FP-B
Purity
CRS, European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
A45653
Product name
4-Chloro-3-(trifluoromethyl)aniline
Purity
99%
Packaging
25g
Price
$34.67
Updated
2025/07/31
TCI Chemical
Product number
C0922
Product name
5-Amino-2-chlorobenzotrifluoride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
C0922
Product name
5-Amino-2-chlorobenzotrifluoride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$64
Updated
2025/07/31
Strem Chemicals
Product number
09-1070
Product name
5-Amino-2-chlorobenzotrifluoride, min. 97%
Packaging
5g
Price
$29
Updated
2024/03/01
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4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Chemical Properties,Usage,Production

Chemical Properties

white to pinkish crystalline powder

Uses

5-Amino-2-chlorobenzotrifluoride is a compound useful in organic synthesis. It also performs a radioprotective activity against ionizing radiations.

Definition

ChEBI: A monochlorobenzene that is the 3-trifluoromethyl derivative of 4-chloroaniline.

Synthesis

777-37-7

320-51-4

General procedure for the synthesis of 2-chloro-5-aminobenzotrifluoride from 2-chloro-5-nitrobenzotrifluoride: In 1.0 mL of 2 wt% TPGS/H2O solution, 1-chloro-4-nitro-2-(trifluoromethyl)benzene (113 mg, 0.50 mmol), Fe nanoparticles (6 mg) and NaBH4 (28.5 mg, 0.75 mmol) were added. The reaction was carried out at room temperature for 2 hours. Upon completion of the reaction, 91.7 mg (94% yield) of 4-chloro-3-(trifluoromethyl)aniline was obtained as a colorless oil (hexane/ethyl acetate = 80/20). The spectral data of the product were in agreement with those reported in the literature.GC-MS analysis showed m/z: 195 [M]+.

References

[1] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 31, p. 8979 - 8983
[3] Angew. Chem., 2016, vol. 128, # 31, p. 9125 - 9129,5
[4] Patent: WO2017/106426, 2017, A1. Location in patent: Paragraph 0084; 0088
[5] Patent: CN108191670, 2018, A. Location in patent: Paragraph 0047; 0050; 0053; 0056; 0057-0059; 0062-0068

4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Preparation Products And Raw materials

Raw materials

Preparation Products

4-CHLORO-3-(TRIFLUOROMETHYL)BENZYL BROMIDE
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4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Suppliers

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View Lastest Price from 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
4-Chloro-3-Trifluoromethyl aniline 320-51-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-28
Shaanxi Dideu New Materials Co. Ltd
Product
4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 320-51-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Amino-2-chlorobenzotrifluoride 320-51-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-13

320-51-4, 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidineRelated Search:

ETHYL 4-CHLORO-3-TRIFLUOROMETHYLCARBANILATE Sorafenib IMpurity Sorafenib related coMpound 8 Sorafenib related compound 10 Sorafenib Related Compound 21 Sorafenib Impurity 1 Sorafenib related coMpound 5 Sorafenib Related Compound 13 Sorafenib related coMpound 1 4-(4-Aminophenoxy)-N-methylpicolinamide Sorafenib IMpurity C Sorafenib Impurity 6 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Sorafenib related coMpound 6 Sorafenib Related Compound 22 N-Methyl-4-chloropyridine-2-carboxamide Sorafenib related compound 11 Sorafenib related coMpound 7

  • 5-AMINO-2-CHLOROTRIFLUOROTOLUENE
  • 5-AMINO-2-CHLOROBENZOTRIFLUORIDE
  • 4-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE
  • 4-CHLORO-3-TRIFLUOROMETHYL-PHENYLAMINE
  • 4-CHLORO-3-(TRIFLUOROMETHYL)ANILINE
  • 4-Chloro-3-(trifluoromethyl)-benzenamine
  • 4-AMINO-1-CHLORO-2-(TRIFLUOROMETHYL)BENZENE
  • 2-CHLORO-5-AMINEBENZOTRIFLUORIDE
  • 2-CHLORO-5-AMINOBENZOTRIFLUORIDE
  • LABOTEST-BB LT00077053
  • TIMTEC-BB SBB003592
  • 3-(Trifluoromethyl)-4-chloroaniline
  • 4-chloro-3-(trifluoromethyl)-benzenamin
  • 6-Chloro-3-aminobenzotrifluoride
  • Aniline, 4-chloro-3-(trifluoromethyl)-
  • Benzenamine,4-chloro-3-(trifluoromethyl)-
  • Benzenamine,4-chloro-3-trifluoromethyl-
  • m-Toluidine, 4-chloro-alpha,alpha,alpha-trifluoro-
  • 5-Amino-2-chlorobenzotrifluoride,97%
  • 5-Amino-2-chlorobenzotrifluoride,min.97%
  • 5-Amino-2-chlorobenzotrifluoride 97%
  • 4-chloro-3-(Trilfuoromethyl)aniline
  • 4-Chloro-5--Amino benzotrifluoride
  • 5-AMINO-2-CHLOROBENZOTRIFLUORIDE (4-CHLORO-3-TRIFLUOROMETHYLANILINE)
  • 2-CHLORO-5-AMINOBENZOTRIFLUORIDE 98%
  • 4-Chloro-α,α,α-trifluoro-m-toluidine, 5-Amino-2-chlorobenzotrifluoride
  • 4-chloro-3-(trifluoromethyl)anilin
  • 5-Amino-2-chlorobenzotrifluoride, min. 97%
  • 5-Amino-2-chlorobenzotrifluoride,99%
  • 4-AMINO-1-CHLORO-2-(TRIF
  • oro-3-(trifL
  • Regofenib impurity 5
  • 5-Amino-2-chlorobenzotrifluoride（2-Chloro-5-aminobenzotrifluoride）
  • 5-AMino-2-chlorobenzotrifluoride, 99% 25GR
  • 5-AMino-2-chlorobenzotrifluoride, 99% 5GR
  • 4-Chloro-alpha,alpha
  • 3-AMino-6-chlorobenzotrifluoride
  • NSC 61405
  • 4-Chlorine-3-(trifluoroMethyl)aniline
  • 4-Amino-1-chloro-2-(trifluoromethyl)benzene 4-Chloro-3-trifluoromethylaniline
  • 4-Chloro-3-(trifluoromethyl)aniline, 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
  • 2 - chloro - 5 - aMino toluene three fluorine
  • Chlorine - 4-3-3 Methylaniline
  • Sorafenib Impurity 5
  • 5-Amino-2-chlorobenzotrifluoride for synthesis
  • Sorafenib Impurity E
  • 5-Amino-2-chlorobenzotrifluoride &gt
  • 4-Chlor-α,α,α-trifluor-m-toluidin
  • 4-Chloro-3-(trifluoromethyl)aniline? (Regorafenib Impurity)
  • Sorafenib Impurity 5(Regorafenib Impurity 5)
  • AI-ZA04
  • 5-Amino-2-chlorobenzotrifluride
  • 4-chloro-α,α,α-trifluoro-m-toluidine
  • 2-chloro-5-aminotrifluorotoluene
  • 320-51-4
  • 320-98-4
  • NH2ClC6H3CF3
  • ClC6H3CF3NH2