PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE
Application- Product Name
- PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE
- CAS No.
- 877997-98-3
- Chemical Name
- PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE
- Synonyms
- Acotiamide Impurity 35;Alcotimide intermediate 2;PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE;Phenyl 2-hydroxy-4,5-dimethyoxybenzoate;Phenyl -2-hydroxy -4,5-dimethyl benzoate;2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester;Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester;Ethyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide);4, 5-dimethoxybenzoic acid, phenyl ester, 2-hydroxy-4, 5-dimethoxybenzoic acid
- CBNumber
- CB4478258
- Molecular Formula
- C15H14O5
- Formula Weight
- 274.27
- MOL File
- Mol file
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Property
- Boiling point:
- 431.2±45.0 °C(Predicted)
- Density
- 1.250±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.83±0.23(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P321060
- Product name
- Phenyl2-Hydroxy-4,5-dimethoxybenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X5044
- Product name
- Phenyl2-hydroxy-4,5-dimethoxybenzoate
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- CHM0294571
- Product name
- PHENYL-2-HYDROXY-4,5-DIMETHOXYBENZOATE
- Purity
- 98.00%
- Packaging
- 25G
- Price
- $1761.38
- Updated
- 2021/12/16
- Product number
- A1476019
- Product name
- Phenyl2-hydroxy-4,5-dimethoxybenzoate
- Purity
- 98+%
- Packaging
- 100g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- 877997983
- Product name
- Phenyl2-hydroxy-4,5-dimethoxybenzoate
- Packaging
- 10g
- Price
- $161.6
- Updated
- 2021/12/16
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Chemical Properties,Usage,Production
Application
2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester is an important intermediate in the synthesis of 2-aminothiazole compounds. 2-Aminothiazole compounds are an important class of heterocyclic compounds in organic medicinal chemistry, possessing a wide range of biological activities. They can be used as local anesthetics and have anticonvulsant, antiviral, antibacterial, and insecticidal effects.
Synthesis
101-02-0
5722-93-0
877997-98-3
(1) Toluene (1.5 g), triphenyl phosphite (2.35 g), 2-hydroxy-4,5-dimethoxybenzoic acid (1.5 g) and concentrated sulfuric acid (40.3 μL) were mixed in a reaction flask under argon protection. The reaction mixture was refluxed under stirring conditions for 2.5 hours. After completion of the reaction, it was cooled to room temperature, methanol (5 g) was added and stirring was continued for 30 min. Subsequently, water (2.5 g) was added to the mixture and stirred for another 30 minutes. The precipitated crystals were filtered and dried under reduced pressure to afford phenyl 2-hydroxy-4,5-dimethoxybenzoate (2.0 g) in 96% yield.
References
[1] Patent: WO2006/22252, 2006, A1. Location in patent: Page/Page column 11
[2] Patent: US2013/253222, 2013, A1. Location in patent: Paragraph 0039
[3] Patent: CN105439977, 2016, A. Location in patent: Paragraph 0016
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE manufacturers
- Product
- phenyl 2-hydroxy-4,5-dimethoxybenzoate 877997-98-3
- Price
- US $150.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- ≥98%
- Supply Ability
- 5000kg/month
- Release date
- 2023-09-15
- Product
- Phenyl2-hydroxy-4,5-dimethoxybenzoate 877997-98-3
- Price
- US $100.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 500t/month
- Release date
- 2023-05-24
- Product
- Phenyl 2-hydroxy-4,5-dimethoxybenzoate 877997-98-3
- Price
- US $100.00/KG
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2021-12-21