2-Hydroxy-4-methyl-3-nitropyridine

Uses

Product Name: 2-Hydroxy-4-methyl-3-nitropyridine
CAS No.: 21901-18-8
Chemical Name: 2-Hydroxy-4-methyl-3-nitropyridine
Synonyms: -3-nitropyridine;Hydroxymethylnitropyridine;4-METHYL-3-NITRO-2-PYRIDONE;4-METHYL-3-NITROPYRIDIN-2-OL;4-METHYL-3-NITRO-2-PYRIDINOL;2-HYDROXY-3-NITRO-4-PICOLINE;4-Methyl-3-nitro-2-pyridinone;2-HYDROXY-4-METHYLNITROPYRIDINE;4-Methyl-3-Nitro-2(1H)-Pyridinone;-Hydroxy-4-methyl-3-nitropyridine
CBNumber: CB4435295
Molecular Formula: C6H6N2O3
Formula Weight: 154.12
MOL File: 21901-18-8.mol

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2-Hydroxy-4-methyl-3-nitropyridine Property

Melting point:: 229-232 °C(lit.)
Boiling point:: 277.46°C (rough estimate)
Density: 1.4564 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: Store at room temperature
solubility: soluble in Dimethylformamide
pka: 8.40±0.10(Predicted)
form: Crystalline Solid
color: Pale yellow
BRN: 139125
InChI: InChI=1S/C6H6N2O3/c1-4-2-3-7-6(9)5(4)8(10)11/h2-3H,1H3,(H,7,9)
InChIKey: HZCWTTHQRMHIIE-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference: 21901-18-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290114
Product name: 2-Hydroxy-4-methyl-3-nitropyridine
Purity: 98%
Packaging: 5g
Price: $199
Updated: 2023/01/07

TCI Chemical

Product number: H1170
Product name: 2-Hydroxy-4-methyl-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: H1170
Product name: 2-Hydroxy-4-methyl-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $121
Updated: 2025/07/31

TRC

Product number: H999833
Product name: 2-Hydroxy-4-methyl-3-nitropyridine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J96751
Product name: 2-Hydroxy-3-nitro-4-methylpyridine
Packaging: 5g
Price: $25
Updated: 2021/12/16

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2-Hydroxy-4-methyl-3-nitropyridine Chemical Properties,Usage,Production

Uses

2-Hydroxy-4-methyl-3-nitropyridine is a useful research chemical.

Chemical Properties

yellow crystalline powder

General Description

The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-3-nitropyridine was studied.

Synthesis

6635-86-5

21901-18-8

4-Methyl-3-nitropyridin-2-amine (compound 8, 11 g, 0.072 mol) was added to 150 mL of water, concentrated sulfuric acid (11 mL) was added slowly with stirring and cooled to 0 °C in an ice bath. Sodium nitrite (9 g, 0.130 mol) was dissolved in 20 mL of water and added slowly dropwise through a long-necked funnel to just below the reaction solution level. The reaction was stirred continuously for 2 h at room temperature and then heated to boiling until the reaction was complete, during which no brown gas escaped. After completion of the reaction, the reaction solution was cooled and the solid product was collected by filtration and dried to give 2-keto-3-nitro-4-methylpyridine (Compound 9, 10.8 g, 97.6% yield). The melting points of the product were 222.3-222.6 °C (aqueous phase) and 231.6-231.8 °C (ethanol phase), which were in agreement with literature reports.

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 7
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 2806
[3] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[4] Chemical and Pharmaceutical Bulletin, 2008, vol. 56, # 6, p. 775 - 780
[5] Chemical and Pharmaceutical Bulletin, 2017, vol. 65, # 1, p. 66 - 81

2-Hydroxy-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Nevirapine

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2-Hydroxy-4-methyl-3-nitropyridine Suppliers

Americas 1 Belgium 1 China 182 Europe 3 France 2 Germany 2 India 26 Japan 2 Switzerland 2 United Kingdom 13 United States 42 Global 276

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View Lastest Price from 2-Hydroxy-4-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Hydroxy-4-methyl-3-nitropyridine 21901-18-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Amino-5-hydroxypyridine 21901-18-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Henan Fengda Chemical Co., Ltd

Product: 2-Hydroxy-4-methyl-3-nitropyridine 21901-18-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

21901-18-8, 2-Hydroxy-4-methyl-3-nitropyridineRelated Search:

METSULFURON METHYL 3-Hydroxypyridine 2,4,6-Collidine 2-Chloro-3-hydroxypyridine Methyl acetate 4-Methylpyridine 4-Methyl-3-nitropyridine 2-Bromo-5-nitropyridine Azamethiphos Bensulfuron methyl 2-Hydroxy-4-methylpyridine 3-Nitro-2-pyridinol CHLOROPHOSPHONAZO III Methyl salicylate 4-Hydroxy-3-nitropyridine Kresoxim-methyl Methylparaben Thiophanate-methyl

4-METHYL-3-NITRO-2-PYRIDINOL

4-METHYL-3-NITRO-2-PYRIDONE

4-METHYL-3-NITROPYRIDIN-2-OL

2-HYDROXY-3-NITRO-4-METHYLPYRIDINE

2-HYDROXY-3-NITRO-4-PICOLINE

2-HYDROXY-4-METHYL-3-NITROPYRIDINE

2(1H)-PYRIDINONE, 4-METHYL-3-NITRO-

Hydroxymethylnitropyridine

4-Methyl-3-Nitro-2(1H)-Pyridinone

2-HYDROXY-4-METHYLNITROPYRIDINE

2-Hydroxy-4-methyl-3-nitropyridine,98%

2-Hydroxy-4-Methyl-3-nitropyridine, 98% 5GR

2-HYDROXY-3-NITRO-4-METHYLPYRIDINE 98+%

2-HYDROXY-3-NITRO-4-PICOLINE (2-HYDROXY-4-METHYL-3-NITROPYRIDINE)

2-Hydroxy-3-nitro-4-picoline 4-Methyl-3-nitro-2-pyridinol 4-Methyl-3-nitro-2-pyridone

4-Methyl-3-nitro-2-pyridinone

4-Methyl-3-nitro-2-pyridinone, 97+%

2-Hydrocy-4-methyi-3-nirropyridine

-Hydroxy-4-methyl-3-nitropyridine

4-methyl-3-nitro-1H-pyridin-2-one

2-Hydroxy-4-methyl-3-nitropyridine&gt

4-methyl-3-nitropyridin-2(1H)-one

-3-nitropyridine

2-Hydroxy-4-methyl-3-nitropyridine ISO 9001：2015 REACH

2-Hydroxy-4-methyl-3-nitropyridin

4-Methyl-3-nitro-1,2-dihydropyridin-2-one

21901-18-8

21091-18-8

Building Blocks

Pyridines

Heterocyclic Building Blocks

C6

Heterocycle-Pyridine series

Pyridines

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

Pyridine

C6