ChemicalBook > CAS DataBase List > 2-Hydroxy-3-trifluoromethylpyridine

2-Hydroxy-3-trifluoromethylpyridine

Product Name
2-Hydroxy-3-trifluoromethylpyridine
CAS No.
22245-83-6
Chemical Name
2-Hydroxy-3-trifluoromethylpyridine
Synonyms
3-Trifluoromethyl-pyridin-2-ol;2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE;BUTTPARK 24\01-66;2-Hydroxy-3-(trifL;2-Hydroxy-3-trifluor;Hydroxy-3-trifluoromethyl;2-Hydroxy-3-trifluoromethyl;3-trifluoroMethyl-2-pyridinol;3-(TRIFLUOROMETHYL)-2-PYRIDONE;3-(Trifluoromethyl)pyridin-2-one
CBNumber
CB9168839
Molecular Formula
C6H4F3NO
Formula Weight
163.1
MOL File
22245-83-6.mol
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2-Hydroxy-3-trifluoromethylpyridine Property

Melting point:
150-153°C
Boiling point:
223.7±40.0 °C(Predicted)
Density 
1.398±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
9.67±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
InChIKey
JHDCDEHVUADNKQ-UHFFFAOYSA-N
SMILES
C1(=O)NC=CC=C1C(F)(F)F
LogP
0.71 at 25℃
CAS DataBase Reference
22245-83-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn,T
Risk Statements 
36/37/38-65-20/21/22-20/21-36-25
Safety Statements 
26-36/37/39-36-45
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2600
Product name
3-(Trifluoromethyl)-2-pyridone
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$45
Updated
2024/03/01
TCI Chemical
Product number
T2600
Product name
3-(Trifluoromethyl)-2-pyridone
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$141
Updated
2024/03/01
TRC
Product number
H971565
Product name
2-Hydroxy-3-trifluoromethylpyridine
Packaging
1g
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-3-23
Product name
2-Hydroxy-3-(trifluoromethyl)pyridine
Purity
98%
Packaging
25g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC4868W
Product name
2-Hydroxy-3-(trifluoromethyl)pyridine
Purity
97%
Packaging
100g
Price
$65
Updated
2021/12/16
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2-Hydroxy-3-trifluoromethylpyridine Chemical Properties,Usage,Production

Description

2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Chemical Properties

White powder

Uses

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

2-Hydroxy-3-trifluoromethylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-3-trifluoromethylpyridine Suppliers

Zhejiang zetian fine chemical co. LTD
Tel
0571-87322520 18957127338
Fax
QQ:800182836
Email
sales@zetchem.com
Country
China
ProdList
450
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58
Shanghai Rolead Chemical Technology Co., Ltd.
Tel
021-69992220 13701886816
Fax
021-69992237
Email
roleadchem@163.com
Country
China
ProdList
4750
Advantage
50
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
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40228
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TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
ProdList
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
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China
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35896
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
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China
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View Lastest Price from 2-Hydroxy-3-trifluoromethylpyridine manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
SHANDONG OUCHEM CO.,LTD.
Product
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99% Min.
Supply Ability
10000KG
Release date
2024-02-25
Shanghai Yongzeng Technology Co.,Ltd
Product
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price
US $0.00/gm
Min. Order
100gm
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-04

22245-83-6, 2-Hydroxy-3-trifluoromethylpyridineRelated Search:


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