2-Hydroxy-3-trifluoromethylpyridine

Product Name: 2-Hydroxy-3-trifluoromethylpyridine
CAS No.: 22245-83-6
Chemical Name: 2-Hydroxy-3-trifluoromethylpyridine
Synonyms: 3-Trifluoromethyl-pyridin-2-ol;2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE;BUTTPARK 24\01-66;2-Hydroxy-3-(trifL;2-Hydroxy-3-trifluor;Hydroxy-3-trifluoromethyl;2-Hydroxy-3-trifluoromethyl;3-trifluoroMethyl-2-pyridinol;3-(TRIFLUOROMETHYL)-2-PYRIDONE;3-(Trifluoromethyl)pyridin-2-one
CBNumber: CB9168839
Molecular Formula: C6H4F3NO
Formula Weight: 163.1
MOL File: 22245-83-6.mol

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2-Hydroxy-3-trifluoromethylpyridine Property

Melting point:: 150-153°C
Boiling point:: 223.7±40.0 °C(Predicted)
Density: 1.398±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 9.67±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
InChIKey: JHDCDEHVUADNKQ-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC=C1C(F)(F)F
LogP: 0.71 at 25℃
CAS DataBase Reference: 22245-83-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,T
Risk Statements: 36/37/38-65-20/21/22-20/21-36-25
Safety Statements: 26-36/37/39-36-45
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2600
Product name: 3-(Trifluoromethyl)-2-pyridone
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: T2600
Product name: 3-(Trifluoromethyl)-2-pyridone
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $127
Updated: 2025/07/31

TRC

Product number: H971565
Product name: 2-Hydroxy-3-trifluoromethylpyridine
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-3-23
Product name: 2-Hydroxy-3-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 25g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC4868W
Product name: 2-Hydroxy-3-(trifluoromethyl)pyridine
Purity: 97%
Packaging: 100g
Price: $65
Updated: 2021/12/16

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2-Hydroxy-3-trifluoromethylpyridine Chemical Properties,Usage,Production

Description

2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Chemical Properties

White powder

Uses

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

Synthesis

142-08-5

2314-97-8

22245-83-6

General procedure: 2-hydroxypyridine (0.19 g, 2.0 mmol) and ferrocene (0.11 g, 0.6 mmol) were accurately weighed and placed in a dry two-necked flask and the atmosphere was replaced under argon protection. Dimethyl sulfoxide (8.0 mL), 3.0 mol/L trifluoromethyl iodine in dimethyl sulfoxide solution (2.0 mL) and 30% aqueous hydrogen peroxide solution (0.4 mL) were added sequentially to the flask, and the reaction mixture was stirred for 20 min at 40 °C to 50 °C. After completion of the reaction, the mixture was cooled to room temperature. The generation of 2-hydroxy-3-trifluoromethylpyridine was confirmed by 19F-NMR analysis using 2,2,2-trifluoroethanol as an internal standard (19F-NMR yield: 64%). Following the subsequent processing steps of Example 1, the target product 2-hydroxy-3-trifluoromethylpyridine was obtained as a white solid (0.081 g, yield: 50%). The structure of the product was determined by 1H-NMR (deuterated chloroform, δ 6.34 (dd, J = 6.9, 5.5 Hz, 1H), 7.65 (d, J = 5.6 Hz, 1H), 7.88 (d, J = 6.9 Hz, 1H), 13.25 (brs, 1H)), 13C-NMR (deuterated chloroform, δ 105.6, 120.4 (q, JCF = 31.4 Hz), 122.7 (q, JCF = 271.3 Hz), 139.2, 140.7 (q, JCF = 4.9 Hz), 161), 19F-NMR (deuterated chloroform, δ -66), and mass spectrometry (m/z: 163 [M]+) confirmed.

References

[1] Patent: EP2080744, 2009, A1. Location in patent: Page/Page column 7-8
[2] Journal of Fluorine Chemistry, 2010, vol. 131, # 1, p. 98 - 105

2-Hydroxy-3-trifluoromethylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-3-trifluoromethylpyridine Suppliers

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View Lastest Price from 2-Hydroxy-3-trifluoromethylpyridine manufacturers

Shandong Jihui Chemical Co., Ltd.

Product: 2-Hydroxy-3-(trifluoromethyl)pyridine 22245-83-6
Price: US $0.00-0.00/KG
Min. Order: 25KG
Purity: Purity: 99%
Supply Ability: 1000tons
Release date: 2025-07-21

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Shanghai Yongzeng Technology Co.,Ltd

Product: 2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price: US $0.00/gm
Min. Order: 100gm
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-04

22245-83-6, 2-Hydroxy-3-trifluoromethylpyridineRelated Search:

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2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE

3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE

3-(TRIFLUOROMETHYL)-2-PYRIDONE

BUTTPARK 24\01-66

3-(Trifluoromethyl)pyridin-2-one

3-Trifluoromethyl-pyridin-2-ol

2-Hydroxy-3-(trifluoromethyl)pyridine 97%

2-Hydroxy-3-(trifluoromethyl)pyridine97%

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3-(Trifluoromethyl)-2-pyridinone

2-Hyddroxy-3-trifluoromethylpyridine

2-Hydroxy-3-trifluor

-Hydroxy-3-trifluoroMethylpyridine

3-(Trifluoromethyl)-2-pyridinone 2-Hydroxy-3-(trifluoromethyl)pyridine

2(1H)-Pyridinone, 3-(trifluoroMethyl)-

3-trifluoroMethyl-2-pyridinol

3-Trifluoromethyl-1H-pyridin-2-one

2-Hydroxy-3-trifluoromrthylpyridine

2-Hydroxy-3-(trifL

2-Hydroxy-3-trifluoromethylpyridine ISO 9001：2015 REACH

2-Hydroxy-3-trifluoromethyl

2-Hydroxy-3-trifluoromethylpyridine 22245-83-6

2-Hydroy-3-trifluoromethylpyridine

3-(Trifluoromethyl)-2(1H)-pyridinone

Hydroxy-3-trifluoromethyl

hydroxy-3-trifluoromethylpyridine

22245-83-6

33252-63-1

Fluorine series

blocks

FluoroCompounds

Pyridines

Pyridine