ChemicalBook > CAS DataBase List > 2-Hydroxy-3-trifluoromethylpyridine

2-Hydroxy-3-trifluoromethylpyridine

Product Name
2-Hydroxy-3-trifluoromethylpyridine
CAS No.
22245-83-6
Chemical Name
2-Hydroxy-3-trifluoromethylpyridine
Synonyms
3-Trifluoromethyl-pyridin-2-ol;2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE;BUTTPARK 24\01-66;2-Hydroxy-3-(trifL;2-Hydroxy-3-trifluor;2-Hydroxy-3-trifluoromethyl;3-trifluoroMethyl-2-pyridinol;3-(TRIFLUOROMETHYL)-2-PYRIDONE;3-(Trifluoromethyl)pyridin-2-one;3-(Trifluoromethyl)-2-pyridinone
CBNumber
CB9168839
Molecular Formula
C6H4F3NO
Formula Weight
163.1
MOL File
22245-83-6.mol
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2-Hydroxy-3-trifluoromethylpyridine Property

Melting point:
150-153°C
Boiling point:
223.7±40.0 °C(Predicted)
Density 
1.398±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
9.67±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)
InChIKey
JHDCDEHVUADNKQ-UHFFFAOYSA-N
SMILES
C1(=O)NC=CC=C1C(F)(F)F
LogP
0.71 at 25℃
CAS DataBase Reference
22245-83-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn,T
Risk Statements 
36/37/38-65-20/21/22-20/21-36-25
Safety Statements 
26-36/37/39-36-45
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2600
Product name
3-(Trifluoromethyl)-2-pyridone
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$45
Updated
2024/03/01
TCI Chemical
Product number
T2600
Product name
3-(Trifluoromethyl)-2-pyridone
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$141
Updated
2024/03/01
TRC
Product number
H971565
Product name
2-Hydroxy-3-trifluoromethylpyridine
Packaging
1g
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-3-23
Product name
2-Hydroxy-3-(trifluoromethyl)pyridine
Purity
98%
Packaging
25g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC4868W
Product name
2-Hydroxy-3-(trifluoromethyl)pyridine
Purity
97%
Packaging
100g
Price
$65
Updated
2021/12/16
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2-Hydroxy-3-trifluoromethylpyridine Chemical Properties,Usage,Production

Description

2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Chemical Properties

White powder

Uses

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

2-Hydroxy-3-trifluoromethylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Hydroxy-3-trifluoromethylpyridine manufacturers

PNP Biotech Co. Ltd
Product
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-13
Nantong Guangyuan Chemicl Co,Ltd
Product
3-(trifluoromethyl)-1H-pyridin-2-one 22245-83-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-10-18
WEIFANG OUCHEM TRADE CO.,LTD.
Product
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99% Min.
Supply Ability
10000KG
Release date
2024-02-25

22245-83-6, 2-Hydroxy-3-trifluoromethylpyridineRelated Search:

2-Chloro-3-hydroxypyridine Azamethiphos CHLOROPHOSPHONAZO III 2-Chloro-3-(trifluoromethyl)pyridine 3-Hydroxypyridine 2,4,6-Collidine 2-(Trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzaldehyde 2-Hydroxypyridine 4-Methylpyridine 4-(Trifluoromethyl)pyridine 2-(Trifluoromethyl)pyridine 3-Trifluoromethylpyridine 2-Hydroxy-6-methyl-5-nitropyridine 2-Hydroxy-4-methoxybenzaldehyde 2-Hydroxy-4-methyl-5-nitropyridine 2-Hydroxy-4-methyl-3-nitropyridine 3-BROMO-6-HYDROXY-2-METHYLPYRIDINE

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  • 3-(TRIFLUOROMETHYL)-2-PYRIDONE
  • BUTTPARK 24\01-66
  • 3-(Trifluoromethyl)pyridin-2-one
  • 3-Trifluoromethyl-pyridin-2-ol
  • 2-Hydroxy-3-(trifluoromethyl)pyridine 97%
  • 2-Hydroxy-3-(trifluoromethyl)pyridine97%
  • 3-(Trifluoromethyl)pyridin-2-ol, 3-(Trifluoromethyl)pyridin-2(1H)-one
  • 3-(Trifluoromethyl)-2-pyridinone
  • 2-Hyddroxy-3-trifluoromethylpyridine
  • 2-Hydroxy-3-trifluor
  • -Hydroxy-3-trifluoroMethylpyridine
  • 3-(Trifluoromethyl)-2-pyridinone 2-Hydroxy-3-(trifluoromethyl)pyridine
  • 2(1H)-Pyridinone, 3-(trifluoroMethyl)-
  • 3-trifluoroMethyl-2-pyridinol
  • 3-Trifluoromethyl-1H-pyridin-2-one
  • 2-Hydroxy-3-trifluoromrthylpyridine
  • 2-Hydroxy-3-(trifL
  • 2-Hydroxy-3-trifluoromethylpyridine ISO 9001：2015 REACH
  • 2-Hydroxy-3-trifluoromethyl
  • 2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
  • 2-Hydroy-3-trifluoromethylpyridine
  • 3-(Trifluoromethyl)-2(1H)-pyridinone
  • 22245-83-6
  • 33252-63-1
  • Fluorine series
  • blocks
  • FluoroCompounds
  • Pyridines
  • Pyridine